The involvement of cardiovascular or respiratory complications in cases of brucellosis are extremely rare. Herein, a case of myocarditis and pneumonia with pericardial effusion, pleural effusion and biliteral pleural thickening with pleural adhesion in a 35-year-old female patient, is described. Using next-generation sequencing, the patient was differentially diagnosed with Brucella-related myocarditis and pneumonitis, and treatment with oral doxycycline, rifampicin, and trimethoprim/sulfamethoxazole, along with intravenous gentamycin, was commenced. Following treatment, the patient was clinically improved. When a patient with brucellosis presents with chest pain, clinicians should be aware of this clinical manifestation. Next-generation sequencing may be used to identify pathogens and provide insights into the disease when appropriate cultures are negative.