Aim: This study aimed to compare the success rate of pulp therapy of non-vital primary molars with inflammatory root resorption when treated using triple antibiotic mix or simvastatin as a component in the root filling material. Methodology: Lesion Sterilization and tissue repair was employed in the treatment of 30 non-vital primary molars exhibiting inflammatory root resorption and furcation radiolucency. The molars included in the study were randomly allocated into 2 equal groups. All root canals were instrumented 1mm from the radiographic apex, and an obturation mix was used to fill the canals to avoid the hollow tube effect. Triple antibiotic paste (TAP) was prepared by mixing ciprofloxacin, cefixime, and metronidazole in a 1:1:1 ratio. It was used as the active agent in group I and mixed with zinc oxide powder and polyethylene glycol + propylene glycol as a vehicle to prepare a filling material. For group II, simvastatin was used as the active agent alone. Following pulp therapy, all teeth were restored with stainless steel crowns, 1-week postoperative. Clinical evaluation was carried out at 1 week postoperative, then at 3, 6, and 12 months while radiographic evaluation was carried out at 6 and 12 months using predetermined criteria.