A rare case of acute ischemic stroke in a young patient with iron deficiency anemia (IDA) is reported. IDA has been suggested to have an association with stroke, but few cases have proven it thus far. Three physiological mechanisms explaining IDA to ischemic stroke include a hypercoagulable state secondary to IDA, thrombocytosis secondary to IDA, and anemic hypoxia induced by IDA. Our paper shows an example of a hypoxia-induced stroke secondary to IDA in a young woman with menorrhagia. Thrombus formation was ruled out as the Magnetic Resonance Angiogram (MRA) showed no evidence. As all other known causes for stroke were ruled out, the patient's IDA is a reasonable cause for her stroke. Iron deficiency decreases the amount of hemoglobin, which consequently decreases the amount of oxygen in the blood resulting in low-oxygen delivery to the brain. This causes hypoxic conditions in the brain, leading to death of brain tissue. Thus, we suggest a possible relationship between IDA and ischemic stroke in young adults. Considering IDA as one of the risk factors for ischemic stroke and treating with timely transfusions would be an important step one can take to prevent stroke.

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BackgroundHIV‐associated Multicentric Castleman's Disease (MCD) is a rare malignant lymphoproliferative disorder in which human herpes virus 8 (HHV8) has been found to be a universal factor. Progressive multifocal leukoencephalopathy (PML) is a rare disease of the central nervous system white matter, which has an increased risk in severely immunocompromised patients. Here we present an interesting patient with newly diagnosed HIV infection with PML and Castleman's disease.Case PresentationForty‐six year old female presented with progressive speech difficulty and left facial droop. Clinical examination was normal except for axillary lymphadenopathy, mild motor dysphagia, and decreased visual acuity on the left eye. Imaging revealed a left temporal lesion and significant cervical lymphadenopathy. HIV testing was positive with CD‐4 count of twenty‐six. Cerebrospinal fluid analysis was negative for malignancy; few scattered lymphoid cells present and JC virus (John Cunningham virus) was detected. Biopsy of axillary nodes showed atypical lymphoid hyperplasia with regressed germinal centers, paracortical expansion and increased plasma cells, suggestive of Castleman's disease. Immunohistochemical stain with HHV8 was negative.ConclusionThis case is presented because of the rarity of occurrence of HIV infection, PML and MCD that has never been reported in the literature.