Reaction of aryl 2-pyridyl ethers
with arylzinc reagents under
catalysis of NiCl2(PCy3)2 affords
aryl–aryl cross-coupling products via selective cleavage of
CAr–OPy bonds. The reaction features a wide substrate
range and good compatibility of functional groups. β-H-free
alkylzinc reagents are also applicable as the nucleophiles in the
transformation, whereas β-H-containing alkylzinc reagents lead
to a mixture of cross-coupling and hydrogenation products.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.