The pharmacological properties of onitin, onitinoside and onitisin, three phenolic pterosins, isolated from Onychium siliculosum have been investigated. Their predominant effects are to inhibit the contraction of isolated guinea-pig ileum. In these three compounds, onitin is the most potent one. Onitin (1 x 10M) inhibits both the D receptor and M receptor of 5-HT. The antagonism of onitin against histamine is non-competitive.
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