Masalah kesehatan gigi selalu memiliki pengaruh yang signifikan bagi kesehatan dan kesejahteraan individu. Peningkatan kebersihan mulut merupakan hal yang sangat penting untuk dievaluasi di masyarakat yang bertujuan untuk menurunkan tingginya penyebaran penyakit infeksi. Hal ini sudah menjadi polemik kesehatan yang masih menjadi tugas besar bagi dunia kesehatan. Maka dari itu banyak peneliti tertarik untuk memanfaakan bahan alami sebagai alternatif selain antibiotik yang jauh lebih aman dari bahan kimia. Bahan alami juga lebih mudah untuk didapatkan dengan harga yang relatif terjangkau. Penelitian ini bertujuan untuk mengetahui efektivitas antibakteri ekstrak daun pepaya California terhadap pertumbuhan bakteri Streptococcus sanguis. Ekstrak daun pepaya california diekstrak dengan metode maserasi dan dibagi menjadi beberapa konsentrasi yaitu 40%, 60% dan 80%. Selanjutnya dilakukan uji efektivitas antibakteri dengan metode disc diffusion (Tes Kirby-Bauer). Berdasarkan hasil uji statistik one way ANOVA menunjukkan nilai signifikansi p=0.0000 (p<0.05) terhadap ketiga kelompok konsentrasi dari ekstrak. Hal ini berarti rata-rata diameter zona hambat ekstrak daun pepaya California di semua konsentrasi, yaitu 40%, 60%, dan 80%, ada perbedaan secara signifikan terhadap pertumbuhan bakteri Streptococcus sanguis dimana rata-rata diameter zona hambat ketiga kelompok tersebut adalah 8,67±0,2160 mm, 9,85±0,1643 mm, 10,58±0,1941 mm. Sebagai kesimpulan, ekstrak daun pepaya dengan konsentrasi 80% terbukti menunjukkan daya hambat yang paling tinggi dalam menghambat pertumbuhan bakteri Streptococcus sanguis.

Introduction: Aggressive periodontitis is a periodontal disease that runs rapidly, characterized by gross alveolar bone loss, the disease is unprompted by complaints, not related to local aspects. Objective: The aim of this study was to determine the effect of Aloe vera hydrogel on the number of neutrophil cells in aggressive periodontitis induced by A. actinomycetemcomitans in Wistar rats. Methods: This type of research is a laboratory experimental design with post-test only design with control group design. This study used 24 Wistar rats divided into 6 groups, namely, negative control group (Basic hydrogel), ibuprofen and hydrogel Aloe vera 2.5%, 5%, 10%, 20%. Results: The test results for the mean number of neutrophil cells in the hydrogel aloe vera group of 2.5%, 5%, 10%, 20%, ibuprofen, and negative controls were 120.50 ± 12.92, 78.25 ± 7.37, 47, 25 ± 4.03, 1.00 ± 0.82, 0.50 ± 0.58, and 217.25 ± 62.26. The results of the oneway Anova statistical test obtained p value = 0.001, which means that there is a difference in the number of neutrophils of Wistar rats in all treatment groups. Conclusion: The conclusion of this study there is the effect of giving hydrogel aloe vera a concentration of 2.5%, 5%, 10%, 20% with ibuprofen on Wistar rats induced by aggressive periodontitis.

Background: Periodontal disease is one of the most common dental and oral health problems. Periodontal disease is characterized by inflammation as well as damage to the periodontal tissues, including the alveolar bone, cementum, gingiva, and the periodontal ligament. Aggregatibacter actinomycetemcomitans is the dominant bacterium in cases of periodontitis. Jatropha curcas plant is one of the ingredients that has been widely used for traditional medicine in the community, especially for the leaves. This plant is rich in active compounds such as alkaloids, tannins, phenols, flavonoids, and saponins, which are effective against gram-positive and gram-negative bacteria. This study aimed to determine the effectiveness of Jatropha extract (Jatropha curcas L.) as an antibacterial against Aggregatibacter actinomycetemcomitans in vitro. Methods: In vitro experimental studies. A total of 28 petri dishes contained bacterial colonies Aggregatibacter actinomycetemcomitans were used and divided into 7 test groups, treatment, and control groups. Obtained data were analyzed using SPSS program. Results: Jatropha extract treatment group with a concentration of 35% to 65% had optimal antibacterial abilities as the dose increased. This study also showed that at a concentration of 25%, Jatropha curcas extract did not have the antibacterial ability. Conclusion: Jatropha curcas extract has an antibacterial effect as the concentration of the extract increases againts Aggregatibacter actinomycetemcomitans.

Introduction: Aggressive periodontitis is a periodontal disease that runs rapidly, characterized by gross alveolar bone loss, the disease is unprompted by complaints, not related to local aspects. Objective: The aim of this study was to determine the effect of Aloe vera hydrogel on the number of neutrophil cells in aggressive periodontitis induced by A. actinomycetemcomitans in Wistar rats. Methods: This type of research is a laboratory experimental design with post-test only design with control group design. This study used 24 Wistar rats divided into 6 groups, namely, negative control group (Basic hydrogel), ibuprofen and hydrogel Aloe vera 2.5%, 5%, 10%, 20%. Results: The test results for the mean number of neutrophil cells in the hydrogel aloe vera group of 2.5%, 5%, 10%, 20%, ibuprofen, and negative controls were 120.50 ± 12.92, 78.25 ± 7.37, 47, 25 ± 4.03, 1.00 ± 0.82, 0.50 ± 0.58, and 217.25 ± 62.26. The results of the oneway Anova statistical test obtained p value = 0.001, which means that there is a difference in the number of neutrophils of Wistar rats in all treatment groups. Conclusion: The conclusion of this study there is the effect of giving hydrogel aloe vera a concentration of 2.5%, 5%, 10%, 20% with ibuprofen on Wistar rats induced by aggressive periodontitis.