Background: Prostate cancer is a leading cause of death in men. Nodular hyperplasia and adenocarcinoma are common causes of prostatic enlargement. Diagnosis of these lesions on routine biopsies can be difficult for pathologists. Immunohistochemical stain p63 can help, but it is costly and not widely available. The present study aimed to evaluate the usefulness of mucin histochemistry in relation to p63 expression in differentiating nodular hyperplasia and adenocarcinoma of prostate. Methods: This study was conducted in the department of pathology at Dhaka medical college from July 2018 to June 2020. 50 cases of prostatic lesions (25 NHP and 25 adenocarcinoma) were examined using histomorphology. The sections were stained with periodic acid Schiff (PAS) to identify neutral mucins and Alcian blue (2.5 pH) to identify acidic mucins. Additionally, p63 antibody was used in immunohistochemistry. Results: NHP showed positivity for neutral mucin (96% with PAS stain) but not for acidic mucin (Alcian blue stain), while prostatic carcinoma showed positivity for both neutral mucin (28%) and acidic mucin (44%). The grade group 1 tumors of prostatic carcinoma showed 100% positivity for acid mucin, with a decrease in Alcian blue staining as the grade increased. P63 was positive in 100% of NHP cases and negative in 100% of prostatic carcinoma cases. Conclusions: Positivity for acidic mucins with Alcian blue stain can be a helpful diagnostic tool to differentiate well differentiated adenocarcinomas from benign lesions where facility for p63 immuno-stain is not available and poor people who cannot afford the cost of immunohistochemistry.

Background: By elucidating the role of PR expression in meningothelial meningiomas, this study may contribute to our understanding of the underlying molecular mechanisms driving tumor development and progression. Additionally, it may provide insights into the potential utility of hormonal therapies as adjuvant treatment options for PR-positive meningothelial meningiomas. Ultimately, this research has the potential to impact clinical decision-making, leading to more personalized and effective management strategies for patients with meningothelial meningioma. Objective: To assess the expression of progesterone receptor in meningothelial meningioma. Method: This descriptive cross-sectional study was carried out at the Department of Pathology, Dhaka Medical College over a period of two years from January 2018 to December 2019. A total of 60 Patient of any age group with histologically diagnosed meningiomas of the central nervous system were included as a sample population. During the collection of specimens, all relevant information were recorded systematically in a prepared proforma. All the cases were numbered chronologically and the same number was given to H&E as well as in immunohistochemically stained slides. Results: It was observed that 55% cases were meningothelial meningioma, 8 (13.3%) patients had atypical meningioma, 5 (8.3%) patients had transitional meningioma, 4 (6.7%) patients had psammomatous meningioma and 1(1.7%) cases had anaplastic meningioma. According to PR expression, It was observed that 56.7% study patients had positive PR expression and 43.3% had negative PR expression. 68.8% patients with age group 51-60 years were found positive PR expression and 50% male patients had positive PR expression and 50% male patients had negative PR expression. In female 59.5% cases showed positive and 43.3% showed negative PR expression. It was found that in meningothelial subtype 72.7% cases were PR positive and 27.3% cases were PR negative. In atypical ..