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Background/Aim: Hepatitis B core (HBc) antibody positivity indicates a history of hepatitis B virus (HBV) infection and latent infection. Patients and Methods: We conducted a retrospective case-control study of 512 and 495 head and neck cancer (HNC) and non-HNC patients treated at the Okayama University Hospital, Head and Neck Cancer Center from 2008-2017. Demographic data and risk factors that might affect HNC diagnosis were analyzed to assess their effects. Results: Cancer diagnosis was found to correlate with HBc antibody positivity [odds ratio (OR)=1.50, 95% confidence interval (CI)=1.09-2.08], smoking (OR=3.03, 95%CI=2.16-4.25), and a previous history of cancer (OR=4.12, 95%CI=2.79-6.09). The HBs antigen positivity rate in both groups was very close to that observed in the general Japanese population. The HBc antibody positivity rate was very high only in the HNC group. Conclusion: HBc antibody positivity and HNC are epidemiologically correlated.

Abstract. Rhabdoid tumor is a highly aggressive neoplasm of unknown cellular origin in humans, usually occurring in the kidney and central nervous system of infants or children. In older patients, it occurs rarely in other organs, including the skin and soft tissues. A subcutaneous mass in a 13-year-old male mixed-breed cat was composed of nests or sheets of round to polygonal cells with glassy eosinophilic cytoplasmic inclusions. Immunohistochemically, many neoplastic cells expressed vimentin, localized to the cytoplasmic inclusions, whereas the cytoplasm of some neoplastic cells was diffusely positive for neuron-specific enolase, neurofilament, or S-100 protein. By electron microscopy, the cytoplasmic inclusions were found to be composed of aggregates of intermediate filaments. These findings are quite similar to the histologic, immunohistochemical, and ultrastructural features of human rhabdoid tumors and the few rhabdoid tumors reported in animals.

Background: The closure of palatal defects after tumor resection or irradiation is performed with either a prosthesis or autogenous tissue; however, there are no clear criteria regarding selection of the method. Thus, this study aimed to investigate the real-world situation and problems of palatal closure using prostheses, and examined patient opinion on how palatal closure using autogenous tissue improved their postoperative quality of life (QOL). Methods: In 5 patients whose palatal defects resulted from treatment for head and neck cancer and were closed with a prosthesis, the palate was closed secondarily with autogenous tissue; a questionnaire on daily life was administered pre-and post-operatively. Results: Functional improvements in terms of speech and eating were achieved in all and in 4 of 5 cases, respectively. In all cases, the QOL was better for palatal closure with autogenous tissue than with the prosthesis. Conclusions: As postoperative QOL was considered to be better when reconstructing the palate with autogenous tissue than with the prosthesis, we recommend to actively select autogenous tissue for palate reconstruction.

ABSTRACT. A 3-year-old, spayed female miniature dachshund was presented for vomiting and anorexia. Thoracic radiographs and CT scan revealed abnormal pulmonary opacities at bilateral caudal lobe. Cytological analysis of the pulmonary mass revealed the presence of large lymphohistiocytic cells and small lymphocytes with occasional neutrophils and plasma cells. An open lung biopsy was performed and a diagnosis of pulmonary lymphomatoid granulomatosis (LYG) was made. The dog was administered CHOP based therapy (modified UW-25), and it survived for 1,022 days after admission. Immunohistochemistry revealed pulmonary lesions consisted of many CD79a positive B cells aggregation and proliferation with prominent angiocentric pattern. This was the first case of canine pulmonary LYG managed by CHOP chemotherapy.KEY WORDS: canine, CHOP, lymphomatoid granulomatosis, pulmonary.J. Vet. Med. Sci. 73(4): 527-530, 2011 Lymphomatoid granulomatosis (LYG) is a unique form of pulmonary angiitis and granulomatosis which was first described by Liebow et al. in 1972 [12]. Histologically it is a necrotizing angiocentric and angiodestructive infiltrative process composed of small lymphocytes, plasma cells, histiocytes and atypical lympho-reticular cells [11,12]. In veterinary medicine, canine pulmonary LYG is a rare pulmonary lymphoproliferative disease; very few treatment studies have been conducted and no standard treatment is established [2,17]. In this report, we describe clinical and pathological findings of a canine LYG, which results in long-term survive with CHOP therapy, modified version of the University of Wisconsin-Madison (UW-25) protocol for canine lymphoma [7].A 3-year-old, spayed female miniature dachshund, weighing 3.5 kg, was presented to Osaka Prefecture University Veterinary Clinical Center for 4 week-history of vomiting and anorexia. Clinical examination revealed pyrexia and dyspnea. A peripheral lymphadenopathy was not recognized. There was no evidence of hepatomegaly or splenomegaly. A complete blood count showed abnormal leukocytosis (40,100 cell/µl; reference range 6,000 to 17,000/µl) with mature neutrophilia (23,258 cell/µl; reference range 3,000 to 11,500 /µl) and lymphocytosis (16,441 cell/µl reference range 1,000 to 4,800/µl). The blood biochemical findings included an increased total protein concentration (8.4 g/dl) with a high globulin concentration (A/ G=0.5). Increased α-2 and γ fraction were identified via serum electrophoresis. The dog was negative for Dirofilaria immitis infestation. Thoracic radiographs revealed abnormal pulmonary opacities at bilateral caudal lobe (Fig. 1). Radiographic evidence of sterna lymphadenopathy was also noted. A chest computed tomographic (CT) scan of the thorax showed bilateral, wedge-shaped opacities (Fig. 2). Cytological analysis of the pulmonary mass, which was performed by fine-needle aspiration revealed the presence of large lymphohistiocytic cells and small lymphocytes with occasional neutrophils and plasma cells. The dog was treated with Enrofloxacin (5 mg/kg po ...