Integrated catalysis is an emerging methodology that can streamline the multistep synthesis of complicated products in a single reaction vessel, achieving a high degree of control and reducing the waste and cost of an overall chemical process. Integrated catalysis can be defined by the use of spatial and temporal control to couple different catalytic cycles in one pot. This primer discusses commonly employed approaches and their underlying mechanisms, and elaborates on how the integration of spatially and temporally controlled catalysis in one pot can deliver the synthesis of complex products with high efficiency. We highlight recent advances, analyze current applications and limitations, and provide an outlook for the future development of integrated catalysis. surface, [28][29][30][31][32][33][34][35] or by taking advantage of microscopic concentration gradients. 18,20,36,37 By preventing incompatible species from coming into contact with each other, efficient integrated processes may be promoted. In addition to spatial control, introducing temporal control can also alleviate compatibility concerns. If two processes compete with or hinder each other's activity, deactivating one while the other is active can help avoid incompatibility. Temporal control may be achieved using a variety of external stimuli [38][39][40][41] to switch between different states of a catalyst that have orthogonal reactivity [G] toward certain substrates.

A dimeric yttrium phenoxide complex supported by a ferrocene Schiff base ligand, [(salfen)Y(OPh)]2 (salfen = (N,N’- bis(2,4-di-tert-butylphenoxy)-1,1’-ferrocenediimine), was synthesized and characterized. According to electrochemical studies and 1H NMR spectroscopy, [(salfen)Y(OPh)]2...

We report on the preparation of synthetically versatile N-carboxyanhydrides (NCAs) directly from amino acids and CO2 using n-propylphosphonic anhydride. Most of the NCAs were isolated with >95% purity after simple...