The fast growing field of microwave and microreactor technology has a significant impact on scaling up when combined with microwave irradiation for a wide variety of transition metal-catalyzed reactions. The combination of reactor design with immobilisation techniques is very important for the flow process, allowing maximal interaction between reagents and a catalyst with no clogging problem. In this review, we have presented the scale-up possibilities for a variety of transition metal-catalyzed C−C bond-forming reactions applying microwave heating and microtechnology.

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Coumarins are well known for their antioxidant and anti-edema activities. Their antioxidant property gets enhanced with a methyl group at the C-4 position of the pyran ring. To increase the antioxidant potential and their hydrophilicity, a lipase (Novozyme 435) catalyzed copolymerization of 4-methylcoumarin diesters and polyethylene glycols (PEGs) has been carried out to give novel copolymers.

In an effort to develop potent anti-inflammatory agents, a series of novel chroman derivatives including acyclic amidochromans, chromanyl esters and chromanyl acrylates have been designed, synthesized and fully characterized. These...