We show that the five-dimensional Maxwell theory with the Chern-Simons term is tachyonic in the presence of a constant electric field. When coupled to gravity, a sufficiently large Chern-Simons coupling causes instability of the Reissner-Nordström black holes in anti-de Sitter space. The instability happens only at nonvanishing momenta, suggesting a spatially modulated phase in the holographically dual quantum field theory in (3 þ 1) dimensions, with spontaneous current generation in a helical configuration. The three-charge extremal black hole in the type IIB superstring theory on AdS 5 Â S 5 barely satisfies the stability condition.

Tissue factor (TF), an initiator of the extrinsic coagulation cascade, is expressed in a wide range of cancer cells and plays important roles in cancer progression and metastasis. Recently, the intracellular function of TF has been revealed to be involved in cancer invasion, independent of the blood coagulation pathway. To evaluate the clinical significance of TF expression, we performed an enzyme-linked immunosorbent assay (ELISA) in the plasma of 67 breast cancer patients and immunohistochemistry in 213 breast cancer tissues. In the ELISA study, we showed an up-regulation of plasma TF concentration in breast cancer patients compared with normal controls. Immunohistochemistry demonstrated that TF was expressed in tumour cells and stromal cells and tumour TF expression closely correlated with stromal TF expression ( P = 0.0005). The concentration of plasma TF was associated with tissue TF expression in both tumour and stroma. The multivariate analysis demonstrated that tumour TF expression was an independent prognostic indicator for overall survival ( P = 0.0452). Our data show that plasma TF concentration reflects tissue TF expression and tumour TF expression can provide some predictive value for prognosis and distant metastasis, which indicates the importance of TF function in tumour progression. © 2000 Cancer Research Campaign

Aims: This phase 3, 26-week, open-label, treat-to-target trial investigated the efficacy and safety of insulin degludec/insulin aspart (IDegAsp) in insulin-naïve Japanese adults with type 2 diabetes. Methods:Subjects were randomized to once-daily injections of IDegAsp (n = 147) or insulin glargine (IGlar) (n = 149), both ±≤2 oral antidiabetic treatments. IDegAsp was given before the largest meal at the discretion of each subject (and maintained throughout the trial); IGlar was dosed according to label. Both insulins were titrated to a target prebreakfast self-measured plasma glucose of 3.9 to <5.0 mmol/l. Conclusions: IDegAsp provided superior long-term glycaemic control compared to IGlar, with similar FPG and doses and numerically lower rates of overall and nocturnal hypoglycaemia (p = NS).

We consider a gravity dual description of time dependent, strongly interacting large-N c N = 4 SYM. We regard the gauge theory system as a fluid with shear viscosity. Our fluid is expanding in one direction following the Bjorken's picture that is relevant to RHIC experiments. We obtain the dual geometry at the late time that is consistent with dissipative hydrodynamics. We show that the integration constants that cannot be determined by hydrodynamics are given by looking at the horizon of the dual geometry. Relationship between time dependence of the energy density and bulk singularity is also discussed. *