In this study of Ibuprofen it is an (NSAIDs) non steroidal anti-inflammatory drug and used as analgesic & anti-inflammatory drug. It can be also used in the treatment of rheumatoid arthritis, osteoarthritis, and primary dysmenorrheal. Ibuprofen is absorbed rapidly, bound avidly to protein, but it has low aqueous solubility so it also lowers the dissolution profile of drug. To overcome this problem, various techniques are used, like solid dispersion, complexation, co-solvency, hydro trophy. nanotechnology approach.The main aim of proposed work was to develop Ibuprofen tablets, sustained release dosage form, for the treatment inflammation and pain in the body. Ibuprofen is used to reduce fever and treatpain or inflammation caused by many conditions such as headache, toothache, back pain, arthritis, menstrual cramps, or minor injury. Sustained release formulation is the drug delivery system that designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of single dose. The tablets were prepared by direct compression method using hydroxypropymethylcelluose (HPMC K4M), Avicel pH 102, magnesium stearate and talc. In the formulation HPMC K4M and magnesium stearate used in varying ratios. Tablets blends were evaluated for loose bilk density, tapped density, compressibility index and angle of repose shows satisfactory results. The compressed tablets were then evaluated for various physical tests like diameter, thickness, uniformity of weight, hardness, friability and drug content. The results of all these tests were found to be satisfactory. The in vitro dissolution study was carried out for 12 hours using paddle method in phosphate buffer (pH6.8) as dissolution media. Formulation F3 showsof drug release at the end of 12 hours.

The present work seeks to investigate the seismic behaviour of typical SMRF framed structure with two types of composite columns. The main objective of this paper is to evaluate the comparison of composite columns i.e., Concrete filled steel tube (CFST) and Concrete encased I section (CES). This paper is mainly emphasis on structural behaviour of multi-storied structure with different vertical geometric irregularities with two different composite columns. The present work deals with the seismic behaviour of 15 storey building assessed through dynamic analysis (response spectrum method) as per IS 1893:2002 for seismic zone IV and soil type medium, using ETABS 2015 software package. It is also to compare and find which composite column is more effective against lateral loads. The models were analysed and results are tabulated and compared for various parameters like time period and frequency, storey displacement and storey drift. Keywords: Concrete filled steel tube, Concrete encased I section, vertical irregular buildings, Response Spectrum analysis, Time period, Storey Displacement, Storey Drift. I. INTRODUCTIONThe buildings in India are constructed with RCC and the adoption of steel structures is generally confined to industrial buildings, which have acquired prominence by adopting composite structural elements. The most important and most frequently encountered combination of two materials steel and concrete, with the application in multi-storey commercial buildings and factories, as well as in bridges. These materials can be used in mixed structural systems, for example, concrete cores encircled by steel tubes, as well as in composite structures where members consisting of steel and concrete act together compositely. These essentially different materials are completely compatible and complementary to each other, they have almost the same thermal expansion, they have an ideal combination of strengths with concrete efficient in compression and the steel in tension, concrete also gives corrosion protection and thermal insulation to the steel at elevated temperatures and additionally can restrain slender steel sections from local or lateral-torsional buckling. However, in recent times, the composite columns are gaining popularity for use in multi-storey buildings by virtue of their excellent static and earthquake resistant properties such as lower mass, high strength, rigidity and stiffness, significantly high toughness and ductility, large energy dissipation capacity. Due to these reasons, composite members are gaining importance for the making of sky-scrapers, infrastructure growth and especially for high rise structures of seismic regions in the world. A steel-concrete composite column is a compression member, comprising either a concrete encased hot-rolled steel section or a concrete filled tubular section of hot-rolled steel and is generally used as a load-bearing member in a composite framed structure. The load carrying capacity of composite columns is more than that of the bare reinforced column ...