Histologic and immunochemical analyses were performed on 38 cases and 33 cases of malignant tumors of the peripheral nerve sheath, respectively. The histologic features consisted of either closely packed or loosely arranged interlacing fascicles of slender spindle cells that showed a wavy pattern. Although no characteristic findings indicative of neurogenic differentiation could be confirmed with anti-S-100-protein, a fair number of positive cells were seen in the area where the tumor cells were loosely arranged and displayed a wavy pattern. When anti-neuron-specific enolase (NSE) and anti-neurofilament antibody (68K, 200K) were applied, they were found to be positive in cells differentiating to ganglion cells and in epithelial cells. Since S-100-protein-positive cells indicate a differentiation to Schwann cells and NSE-positive cells and neurofilament-positive cells to nerve cells, it was concluded that immunohistochemistry can serve as an effective supplementary method for the diagnosis of malignant tumors of the peripheral nerve sheath.

The present study Included 46 cases of eosinophilic lymphfolliculoid granuloma(Kimura's disease), which occurred mainly in males between the ages of 11 to 52 years. The common sites were the soft tissue of the head and neck region. Although recurrence was not infrequent, the clinical course was benign. Laboratory findings revealed eosinophilia and frequent elevation of serum IgE. The histological characteristics consisted of proliferation of lymphoid follicles and granulation tissue with infiltration of eosinophils, mast cells, plasma cells, lymphocytes, and histiocytes, some degree of vascular proliferation, and fibrosis. With the appliance of unlabeled peroxidase‐antiperoxidase method, a marked reticular reaction of IgE was confirmed in the germinal center of the folliculoid structure, and there were quite a number of IgE producing plasma cells. Many mast cells with IgE bound to their cell surface were seen in the granulation tissue. Toluidine blue staining and electron microscopy revealed fairly well preserved granules in mast cells, being quite different from the changes seen in type I allergy.

A case of a 66 years old female who had a nephrogenic adenoma recurring three times during a 6 months course of her illness is reported. With each recurrence, the lesion moved toward the urethral orifice, suggesting an intimate relationship between the recurrent process and physical stimuli to the mucosa. Electron microscopy revealed merely non‐specific morphological features of epithelial cells in the lesion. There were no positive morphological clues in the lesion for supporting the lesion to resemble mesonephric and/or mesodermal tissue. The diagnostic term of tubular metaplasia for the lesion is preferable instead of nephrogenic adenoma.

ABSTRACT.Purpose: The aim of the study is to describe a case of suspected endotoxininduced uveitis associated with septic endogenous endophthalmitis followed by antibiotic-induced endotoxemia. Methods: The human leukocyte antigen (HLA) typing of peripheral leukocytes was studied by lymphocytotoxicity technique. Histological and immunohistochemical studies of paraffin embedded specimen were conducted. Results: Findings of HLA typing revealed positive reaction for B 51, Cw 3, DR 8, DR 11, DQ 3. The vitreous body of an eviscerated eye was occupied by the non-specific granulomatous tissue, composed of fibroblast, plasma cells, and Sudan black staining positive foamy cells, including melaniferous phagocytes, identified as CD 68 positive macrophage. Conclusion: It is suggested that antibiotic-induced endotoxemia of a patient with septic endogenous endophthalmitis produced endotoxin-induced uveitis under an upregulation of HLA and endotoxin activated macrophages may release cytokines, followed by fibrin formation and subsequent granuloma.Key words: Penicillin-binding proteins -endotoxemia -imipenem/cilastatin -septic endogenous endophthalmitis -liver abscess -endotoxin-induced uveitis -intravitreal granuloma.Acta Ophthalmol. Scand. 1999: 77: 110-113 Copyright C Acta Ophthalmol Scand 1999. ISSN 1395-3907 I t is described that systemic or local injection of endotoxin, the lipopolysaccharide (LPS) constituents of gram-negative bacterial outer membranes, will induce inflammation in several organs including eyes (Forrester et al. 1980;Rosenbaum et al. 1980). This inflammatory process characterized by an acute anterior uveitis is described as endotoxininduced uveitis (EIU). EIU in various kinds of animals has been established as an experimental model for human uveitis associated with gram-negative bacterial infection, such as ankylosing spondylitis, acute anterior uveitis and Reiter's syndrome. A clinical feature of EIU is an increase in systemic vascular permeability under an upregulation of major histocompatibility complex class II antigen expression on ocular tissue (Forrester et al. 1980;Rosenbaum et al. 1980). This report describes a case of suspected endotoxin-induced uveitis associated with septic endogenous endophthalmitis followed by antibiotic-induced endotoxemia. Case reportA 68-year-old woman was admitted because of an acute endogenous endophthalmitis on the day of the initial observation, although 9 days after the onset.Visual acuity was CF at 1 ft in her right eye, and 0.6 (1.2 Xπ0.75 DΩcyl-1.50 D180ae) in the left. Ocular sonographic examinations revealed shallow anterior chamber, vitreous opacity, abnormal shadow around the optic nerve, intraorbital opacification and thickening of the posterior eyeball, however, no signs of the intraocular and orbital shadow of a foreign body or tumor were detected. A CT scan showed thickening of left cornea, globe wall and extraocular muscles, and inflammatory changes, such as opacities of intraorbital lipids. Laboratory data showed an increase of serum transaminases, g-g...