Aims/hypothesis The aim of this study was to examine the association between HbA 1c variability and the development of microalbuminuria as defined by an albumin/creatinine ratio ≥3.4 mg/mmol (≥30 mg/g) in at least two of three consecutive urine samples in Japanese patients with type 2 diabetes. Methods HbA 1c level was measured in 812 serially registered normoalbuminuric adults aged 21-79 years with type 2 diabetes. After registration, a 1-year period to establish baseline values for mean HbA 1c and HbA 1c variability (measured as the intrapersonal SD of serially collected HbA 1c ) was decided upon. The association between HbA 1c variability and the development of microalbuminuria was determined by Cox regression analysis after adjustment for other risk factors for microalbuminuria.

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