We herein report a study on the intelligent control of microfluidic systems using reinforcement learning. Integrated microvalves are utilized to realize a variety of microfluidic functional modules, such as switching of flow pass, micropumping, and micromixing. The application of artificial intelligence to control microvalves can potentially contribute to the expansion of the versatility of microfluidic systems. As a preliminary attempt toward this motivation, we investigated the application of a reinforcement learning algorithm to microperistaltic pumps. First, we assumed a Markov property for the operation of diaphragms in the microperistaltic pump. Thereafter, components of the Markov decision process were defined for adaptation to the micropump. To acquire the pumping sequence, which maximizes the flow rate, the reward was defined as the obtained flow rate in a state transition of the microvalves. The present system successfully empirically determines the optimal sequence, which considers the physical characteristics of the components of the system that the authors did not recognize. Therefore, it was proved that reinforcement learning could be applied to microperistaltic pumps and is promising for the operation of larger and more complex microsystems.

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