Background and Objectives: Islamic work ethics is influenced by several variables, such as some psychological components. In this regard, the present study aimed to investigate the relationship of flexibility and resilience with Islamic work ethics. Methods: The statistical population of the current descriptive-correlational study included all the employees of Shahid Mahallati Hospital in Tabriz in 2019. A total of 200 individuals were selected using nonprobability convenience sampling and answered the questionnaires of resilience, flexibility, and Islamic work ethic. The obtained data were analyzed in SPSS software using the Pearson correlation coefficient and regression test. A p-value less than 0.05 was considered statistically significant. Results: As evidenced by the obtained results, Islamic work ethic has a positive significant correlation with the components of resilience (personal competence (P<0.001), confidence in one's instincts (P<0.003), positive acceptance of change and secure relationships (P= 0.001), control and spiritual influences (P<0.004) and the components of flexibility (task flexibility (P<0.008), skill flexibility (P<0.001) and behavioral flexibility (P <0.00)). It was also found that resilience with 60% and flexibility with 45% can predict Islamic ethics among the staff of Shahid Mahallati Hospital in Tabriz. Conclusion: Considering the impact of resilience and flexibility components on Islamic ethics, it can be concluded that people with a high degree of resilience and flexibility demonstrate a stronger tendency and commitment to Islamic ethics.