Abstract Background Cardio vascular disease (CVD), a group of disorders of heart and blood vessels. It is the leading cause of death globally including Nepal. The major factors which increase the risks are tobacco chewing/smoking, raised blood cholesterol level, high blood pressure, physical inactivity, overweight, obesity, excessive alcohol consumption, age, sex and heredity etc. Therefore, the aim of this study was to assess the level of knowledge and attitude regarding risk factors of cardio vascular disease among general people residing in Dhamboji-1,Nepalgunj, Banke; Nepal. Methods A descriptive cross-sectional research design was adopted for the study and entirely based on primary data collected through structured and self-administered questionnaires during the month of July 2019. Non-probability convenience sampling technique was used to select 100 general people residing in Nepalgunj, Banke. The collected data were analyzed and summarized through descriptive as well as inferential statistics using SPSS software (version 21). The descriptive analysis was performed using frequencies, percentage etc. and for the inferential part of the study, chi-square test (\({{\chi }}^{2}\)-test) was used. Results The results of the study revealed that among total 100 respondents; 33 (33.0%) of the respondents had poor knowledge, 35(35%) of the respondents had average knowledgee and 32(32.0%) had good level of knowledge regarding risk factors of cardio vascular disease. Likewise, the majority of respondents 68(68.0%) had unfavourable attitude, 32(32.0%) had neutral attitude and none of the respondents had favourable towards risk factors of cardio vascular disease. There was significant association between knowledge and educational status (p value = 0.010) and types of family (p value = 0.031). However, there was no statistically significant association between attitude and other demographic variables such as age, sex, family income, occupation, educational status, types of family, religion, marital status, level of education, present illness and personal habit. Conclusion The findings of the study conclude that, though the attitude was unfavourable but the knowledge was average towards risk factors of cardio vascular disease among general people. Thus, comprehensive interventions against all risk factors should be planned and implemented to reduce the future burden of CVD in general people of Nepal.