Scrub typhus is an endemic illness transmitted by vectors and induced by bacteria. It is the most common and severe rickettsial disease. There are many more cases every year with a significant case fatality rate. Despite being a serious public health threat in India, it is uncertain how widespread and burdensome scrub typhus is. The scarcity of statistical information and pertinent health records on scrub typhus in the outbreak region demonstrates that there is still a significant knowledge gap about this neglected illness. Clinical manifestations of this illness include kidney failure, disability, and severe kidney failure. Undifferentiated symptoms, late diagnosis, and treatment failure are all responsible for deaths. Knowing about this disease is important from a public health point of view due to difficulties in specific diagnosis and a shortage of laboratory services in so many places. India is known to have scrub typhus cases, and doctors should be aware of this potentially dangerous but easily curable illness. The disease is highly difficult to identify clinically from other acute afebrile infections due to common symptoms and a paucity of the lesion in the Indian population. The mainstay of diagnosis is antibody-based serological testing. Within the first week of symptoms, scrub typhus can be diagnosed using molecular and serological tests. Our objective is to identify how severe scrub typhus is in India and to investigate the current epidemiology, etiology, complications, management, and treatment of the disease in both long-established endemic regions and new infection foci.

No abstract

Achromobacter xylosoxidans , also known as Alcaligenes xylosoxidans , is a low-virulence, non-fermenter gram-negative bacillus mainly found in marine environments. We report a detailed series of four high-risk cases of septicemia with the common variable of positive blood cultures for A. xylosoxidans . All four blood isolates were multi-drug resistant and susceptible to meropenem and trimethoprim-sulfamethoxazole. Two patients responded well to the treatment with meropenem and trimethoprim-sulfamethoxazole and two patients died. It should never be assumed that Achromobacter is a contaminant even though it is relatively infrequently isolated from clinical samples. This infection can progress to fatal bacteremia, even in otherwise healthy people, and it can potentially cause severe conditions in premature infants. With only a limited number of antibiotics demonstrating bactericidal properties, the possibility of failure in empirical treatment is significant. As a result, it is important to have a precise comprehension of this uncommon yet deadly illness in order to increase the probability of successful treatment.

No abstract