Background: Pharmaceutical inhibition of host response pathways may be an adjunctive or alternative strategy for treating periodontal diseases. In addition to inhibition of prostaglandin synthesis, aspirin is known to modify the action of cyclooxygenase, changing its activity to a lipoxygenase and leading to formation of lipoxins which have a proresolving effect. This study evaluated the periodontal attachment level of subjects on long-term low dose aspirin therapy. Methods: Oral hygiene index simplified, clinical attachment loss and bleeding index were recorded for 162 subjects who were on long-term (>6 months) low dose (75 mg and 150 mg) aspirin therapy (study group) and 146 subjects not taking the drug (control group). Results: Mean clinical attachment loss was 2.38 ± 0.49 mm in the control group and 2.01 ± 0.69 mm in the study group. The difference was statistically significant at p < 0.001. Correlation analysis suggested that there was a negative correlation between clinical attachment loss and duration of aspirin intake but the clinical attachment loss was not significantly different in the two dosage groups. Conclusions: The results of this study suggest that low dose aspirin may reduce the risk of periodontal attachment loss. This hypothesis needs to be tested by larger sample sized prospective cohort studies.

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A novel series of coumarinyl Mannich bases (3a-1) have been synthesized by reacting 3-acetyl coumarin (1) with various substituted secondary amines (2a-1) in presence of paraformaldehyde. The structures of the newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR and HRMS (high resolution mass spectral) data. Title compounds were screened for in vivo acute anti-inflammatory activity using the carrageenan-induced rat paw edema assay model. Among the compounds tested, 3-[3-(diethylamino)propanoyl]-2H-chromen-2-one (3a)and 3-[3-(piperidine-1-yl) propanoyl]-2H-chromen-2-one (3c) showed 63.1 and 66.7% inhibition, respectively, as compared to the standard drug diclofenac (CAS 15307-86-5, 68.8%). These potent compounds showed encouraging analgesic andantipyretic activities.

Compounds (Ia) and (Ic), the most potent compounds, exhibit encouraging analgesic and antipyretic activities. -(BOLAKATTI, G. S.; MADDI*, V. S.; MAMLEDESAI, S. N.; RONAD, P. M.; PALKAR, M. B.; SWAMY, S.; Arzneim.-Forsch. 58 (2008) 10, 515-520; Dep. Pharm. Chem., KLE Coll. Pharm., Karnataka 575 025, India; Eng.) -H. Toeppel 09-136

Analogues. -A variety of dihydropyridine derivatives (IV) (35 examples) is synthesized by three-component condensation of acetoacetamide (I) with aromatic aldehydes and amines. Some derivatives, e.g. (IVd) and (IVe), exhibit a moderate to good bronchodilatory activity. -(SURESH, T.; SWAMY, S. K.; REDDY*, V. M.; Indian J.