The study demonstrates the potential of optimised Eudragit/Surelease-coated capecitabine-pellets for effective colon-targeted delivery system to avoid frequent high dosing and associated systemic side effects of drug.

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Gastric ulcer is one of the major health problems in developing countries. Furthermore, high cost and of adverse effects are seen with the long term use of allopathic drugs in treatment of ulcer which are diminished by the use of herbal drugs. The aim of this study is to evaluate antiulcer activity of crude extract of Dalbergia sissoo leaves on experimentally induced gastric ulcer in wistar albino rats. Methodology involves screening for antiulcer activity of the plant using pylorus ligation and Indomethacin induced ulcer models in albino rats using 4 groups as; control (Tween 80 1 % v/v solution, 5 ml/kg), standard (Ranitidine 80 mg/kg), 250 mg/kg leaves extract and 500 mg/kg leaves extract given respective doses orally (p.o.). The parameters viz. mean ulcer index, percentage protection, gastric pH, protein, carbohydrate, pepsin, free and total acidity and ratio of total carbohydrates and proteins (TC:TP) were determined. The result showed the significant decrease in mean ulcer index of the leaves extract treated group in both the models compared to control. Furthermore, as obvious from pylorus ligation model the offensive factors like free and total acidity, pepsin content and protein content were decreased to significant levels whereas the defensive factors like total carbohydrate content and TC:TP ratio were increased significantly compared to control in dose dependent manner. The study concluded that leaves extract of Dalbergia sissoo had significant antiulcer activity and was not only effective in reducing the development of gastric ulcer but also increasing the healing of the gastric ulcer in dose dependent manner.

Objective: The main objective of the present study was to design and evaluate a time-controlled single unit oral pulsatile drug delivery system containing salbutamol sulfate for the prevention of nocturnal asthma attacks.Methods: Drug containing core tablets (C1-C10) with different composition of superdisintegrants such as sodium starch glycolate, croscarmellose sodium, and crospovidone were prepared by direct compression technique. The fast disintegrating core tablet formulation was selected, and press-coated tablets (P1-P11) were prepared with different compositions of hydrophobic and hydrophilic polymers: Ethylcellulose-20 (EC-20), hydroxypropyl methylcellulose K4M, and low substituted hydroxypropyl cellulose (L-HPC LH11). The coating polymers were selected and quantified based on in vitro lag time and drug release profile in simulated gastric and intestinal fluids.Results: Formulation C10 with 7.5% crospovidone showed least disintegrating time, i.e., 0.31 min and was selected as the best immediate release core tablet. The press-coated tablet formulation P11 having 360 mg barrier layer of EC-20 and L-HPC LH11 in ratio 14:1 over the core tablet C10 showed rapid and complete drug release nearly after 6 h lag time. Accelerated stability studies of the optimized formulation P11 indicated no significant difference in release profile after a period of 6 months.Conclusion: The in vitro dissolution study showed that lag time before drug release was highly affected by the coating level and nature of coating polymer used. Time-controlled pulsatile release tablets can be prepared using press-coating techniques.