Introduction:The prediction of gestational diabetes mellitus (GDM) by serum adiponectin levels has shown promise in Western literature. This study looks at the first trimester serum adiponectin levels as a predictor of gestational diabetes in Indian women.Material and Methods:A total of 450 pregnant women were screened at 11-- 13 weeks of gestation and serum samples were stored. All the women underwent an oral glucose tolerance test to diagnose GDM by International Association of Diabetes and Pregnancy study Group criteria at 24-- 28 weeks of gestation. Amongst these, 45 women who had developed GDM were compared with 45 controls. The first trimester serum adiponectin levels were compared between the two groups.Results:Mean first trimester adiponectin in GDM and non-GDM group was 7.21 ± 2.49 μg/ml and 12.20 ± 2.91 μg/ml, respectively (P < 0.001). Logistic regression revealed that low adiponectin was the strongest independent risk factor followed by body mass index and HbA1c. Receiver operating characteristic curve revealed that a cut-off value of adiponectin of 9.10 μg/ml in the first trimester was associated with a sensitivity of 100% and specificity of 95.6% in predicting GDM.Conclusions:This is the first study from India which has studied the prediction of GDM by first trimester adiponectin levels. First trimester serum adiponectin may be a strong predictor of GDM in Asian Indian women.

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Suicide is the eighth leading cause of death in males, while strangulation injuries account for approximately 2.5% of all traumatic deaths worldwide. Hanging or 'self-suspension' is a form of ligature strangulation where the pressure is produced by the weight of the body itself. It is easily accessible, comparatively painless, almost always suicidal and cheap method of committing suicide. These attributes make it one of the most common methods of committing suicide all over the world. We report a case of isolated posterior inferior cerebellar artery stroke secondary to hanging, (which is a very rare entity) in a 15 years old boy brought in an unconscious state following a suicide attempt to the emergency in GTBH, Delhi. He presented there with a Glasgow Coma Scale score of 6/15 ,ligature mark over the neck, normal vital signs with low oxygen saturation by pulse oximeter, cyanosis, subconjunctival hemorrhage and positive bilateral Babinski sign. The patient was intubated and put on ventilator support in view of respiratory failure. Patient's magnetic resonance imaging (MRI) brain was done which showed left posterior inferior cerebellar artery territory infarct with cytotoxic edema in bilateral thalami, most likely due to hypoxia. After vigorous treatment in the intensive care unit with fluid restriction, mannitol and intravenous antibiotics he was extubated and transferred to the general ward with glasgow coma scale score of 8/15 (E4V1M3). Later patient was discharged from the hospital and with an advice to follow up in medical and pshychiatry outpatient departments. Survival and recovery after partial hanging is possible if proper care is given as early as possible. We also need to understand the changes which adolescents face in their day to day life and hence be more alert to any social, emotional or professional stress in their life. Also, we should provide counseling and necessary support so that such accidents are deterred.