The relationship between sinusitis and ischemic stroke is unexplored. The anatomic proximity between the paranasal sinuses and the internal carotid artery suggests that inflammation of the sinuses could easily extend to the intracranial vasculature. We report 4 patients with acute ischemic stroke and extensive disease of the paranasal sinuses. All patients had large vessel stroke involving the internal carotid artery territory. All patients had extensive disease of the sphenoid and other sinuses. The sinus disease was demonstrated by magnetic resonance imaging. These case report observations suggest a relationship between inflammation of the paranasal sinuses, particularly sphenoid sinusitis, and ischemic stroke.

A 20-year-old boy presenting daily febrile episodes was suspected to have developed acute hepatic failure. Serologic tests ruled out infectious and autoimmune causes apart from drug toxicity. During clinical examinations, he was found to have generalized enlarged lymph nodes that were then taken biopsy. It was diagnosed as classical Hodgkin's lymphoma based on histological examination of the lymph node. A bone marrow biopsy showed marrow infi ltration by Hodgkin's lymphoma with hemophagocytosis and secondary myelofi brosis. A percutaneous liver biopsy demonstrated hepatic involvement of the same disease. After an extensive work-up, the cause of liver failure was figure out to be only attributed to the involvement of the lymphoma. Hodgkin's lymphoma as a cause of hepatic failure is rare and young patients diagnosed as Hodgkin's lymphoma causing hepatic failure has been reported very rarely so far.

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Introduction: Coronary heart disease (CHD) is a major cause of mortality and morbidity all over the world. According to a report of World Health Organization (WHO) in 2005, cardiovascular disease (CVD) caused 17.5 million (30%) of the 58 million deaths that occurred worldwide. While the prevalence and mortality due to CHD is declining in the developed nations the same cannot be held true for developing countries. Aims And Objective: This study aimed to establish the role of Gray Scale USG and carotid artery Doppler study as a leading investigation in general population presenting with Stable Ischemic Heart Disease. It intended to evaluate the frequency and degree of carotid artery stenosis in these patients & also assess the morphology of atherosclerotic plaque and IMT which are clearly related to pathogenesis and aid in planning and management. Materials And Methods: Adult persons attending to Nilratan Sircar Medical College & Hospital, Kolkata both at OPD and Ward, with Stable Ischemic Heart disease that has undergone coronary angiography were chosen as the Study population. Result And Analysis: Our study showed that 62 % of the patients were above 60 years of age. 84 % of our patients were male.74% of our patients had history of smoking. 70 % of our patients had type 2 diabetes mellitus. 72 % of our patients were dyslipidemic. 78% of the patients were hypertensive. 80 % of patients had increased carotid artery tunica intima media thickening. 66 % of patients had presence of atheromatous plaque in carotid arteries. Summary And Conclusion: However, our study did corroborate with the other available studies except for few deviations like increased number of modiable risk factors in our group. Our study clearly demonstrated Metabolic syndrome –X as a strong risk factor for ischemic heart disease and also suggested early medical treatment can prevent future recurrence. Larger multicentric trials may be necessary in future, for further validation

INTRODUCTION: β-thalassaemia is an inherited disorder of haemoglobin characterized by an absence or reduced synthesis of the β-globin chain. The net result is an excess of α-chains, which precipitate and destroy the red cell precursors, leading to anaemia, skeletal changes, splenomegaly and numerous other complications. Treatment is by regular blood transfusion coupled with iron chelation therapy to prevent iron accumulation and organ damage. AIM: To assess the autonomic and peripheral nerve function in patients with thalassaemic syndrome. MATERIALAND METHODS: Patients attending the Thalassaemia Clinic of Medical College Hospital, Kolkata. Indoor patients from Medicine st th ward and Institute of Haematology and Transfusion Medicine wards of Medical College Hospital, Kolkata from 1 May 2008 to 30 April 2009. After inclusion patients were divided into following groups: Group1 (THAL1): Patients requiring regular blood transfusion and are either receiving inadequate iron chelation or no iron chelation at all. Group2 (THAL2): Patients who require regular blood transfusion and are receiving adequate iron chelation. Group3 (THAL3): Patients who do not require regular blood transfusion RESULT: The median value of distal latency of right common peroneal nerve is slightly increased in all 3 groups. The normal value should be < 4.55ms, thus increase in distal latency is seen in all 3 groups. The median values of distal latency of left common peroneal nerve as well as distal latency of common peroneal nerve as a whole is within normal limits. Distal latency of common peroneal nerve (p value=0.012). Proximal latency of left common peroneal nerve(p value=0.013). Proximal latency of common peroneal (p value=0.001) CONCLUSION: There is demyelinating type of neuropathy of right common peroneal nerve of all the groups. This indicates presence of motor peripheral neuropathy in patients of thalassaemia. All other latencies and amplitudes of both motor and sensory nerves are within normal limits. There were statistically increased motor latencies in patients receiving iron chelation therapy with adequate chelation when compared to the other groups, although the overall latency was within acceptable limits of the laboratory standards. This may be due to subclinical affection of the motor nerves in the form of demyelination. Therefore, the role of toxic effects of iron chelator on peripheral nerves needs to be studied further.