Pantoprazole is extensively metabolized in the liver and has a total serum clearance of 0.1 l/h/kg, a serum elimination half-life of about 1.1 h, and an apparent volume of distribution of 0.15 L/kg. 98% of pantoprazole is bound to serum proteins. Elimination half-life, clearance, and volume of distribution are independent of the dose. Almost 80% of an oral or intravenous dose is excreted as metabolites in urine; the remainder is found in feces and originates from biliary secretion. The clearance of pantoprazole is only slightly affected by age, with its half-life being approximately 1.25 h in the elderly. Pantoprazole is an acid labile drug that requires protection from degradation in acidic media. Hence, co-crystallization of pantoprazole sodium with appropriate co-formers will inhibit its degradation in acidic medium ensuring fast release in the stomach. The acid-labile drugs for oral administration may also be protected from gastric acidity by inhibiting its degradation upon entering into acidic environment. So, the current approach includes co-crystallization of the provided drug with appropriate co-former which prevents degradation of drug by quick absorption and protects the drug from low pH. Apart from that, the formulations also modulate or control the drug release for an immediate action. Keywords: Pantoprazole sodium, Co-crystal, solvent drop method, Co-former.

Co-crystals are defined as crystalline complexes of two or more neutral molecular constituents bound together in the crystal lattice through non covalent interactions. This article summarized about the co-crystal definition, its importance along with characterizations and screening and production methods. From the literature survey, it can be concluded that improvement of performance characteristics of APIs using co-crystallization is a shows potential approach. One of the key aspects of this technique is that it can be useful to all APIs affliction from poor aqueous solubility.  Co-crystallization moves toward is flourishing now adays due to its immaculate effect of solubility on poorly dissolvable drugs, especially those having weakly ionisable group and neutral compounds. Meanwhile co-crystallization will also put an effort into upgrading of other physicochemical properties of drugs such as chemical stability, flowability etc. Keywords: Co-crystals, characteristics, screening, productions, solubility