Background: Medical test orders can display the physiological functions of patients by using medical means. The medical staff determines the patient's condition through medical test orders and completes the treatment. However, for most patients and their families, there are so many terminologies in the medical test list and they are inconvenient to understand and query, which would affect the patients’ cognition and treatment effect. Therefore, it is especially necessary to develop a consulting system that can provide related analysis after getting medical test data. Objective : This paper starts with the information acquisition and speech recognition. It proposes a natural scene information acquisition and analysis model based on deep learning, focusing on improving the recognition rate of routine test list and achieving targeted smart search to allow users to get more accurate personalized health advice. Methods : Based on medical characteristics, considering the needs of patients, this paper constructs an APP-based conventional medical test consultation system, using artificial intelligence and voice recognition technology to collect user input; analyzing user needs with the help of conventional medical information knowledge database. Results: This model combines speech recognition and data mining methods to obtain routine test list data and is suitable for accurate analysis of problems in routine check-up procedure. The app provides effective explanations and guidance for the treatment and rehabilitation of patients. Conclusion: It organically links the Internet with personalized medicine, which can effectively improve the popularity of medical knowledge and provide a reference for the application of medical services on the Internet. Meanwhile, this app can contribute to the improvement of medical standards and provide new models for modern medical management.
Promoters are DNA non-coding regions around the transcription start site and are responsible for regulating the gene transcription process. Due to their key role in gene function and transcriptional activity, the prediction of promoter sequences and their core elements accurately is a crucial research area in bioinformatics. At present, models based on machine learning and deep learning have been developed for promoter prediction. However, these models cannot mine the deeper biological information of promoter sequences and consider the complex relationship among promoter sequences. In this work, we propose a novel prediction model called PromGER to predict eukaryotic promoter sequences. For a promoter sequence, firstly, PromGER utilizes four types of feature-encoding methods to extract local information within promoter sequences. Secondly, according to the potential relationships among promoter sequences, the whole promoter sequences are constructed as a graph. Furthermore, three different scales of graph-embedding methods are applied for obtaining the global feature information more comprehensively in the graph. Finally, combining local features with global features of sequences, PromGER analyzes and predicts promoter sequences through a tree-based ensemble-learning framework. Compared with seven existing methods, PromGER improved the average specificity of 13%, accuracy of 10%, Matthew’s correlation coefficient of 16%, precision of 4%, F1 score of 6%, and AUC of 9%. Specifically, this study interpreted the PromGER by the t-distributed stochastic neighbor embedding (t-SNE) method and SHAPley Additive exPlanations (SHAP) value analysis, which demonstrates the interpretability of the model.
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