A development of Groebke‐Blackburn‐Bienaymé (GBB) reaction was shown by the application of Etidronic acid as a green catalyst. A number of 1H‐imidazo[1,2‐b]pyrazoles derivatives were prepared via multicomponent GBB reaction in one pot sequential steps by the condensation of 5‐amino‐1H‐pyrazole, aldehyde and isonitrile. Here, we have demonstrated the development of GBB protocol by the utility of Etidronic acid in milder reaction medium to modify and simplify the existing synthetic strategies that removes hazardous acids, toxic solvents and drastic conditions with sustainable product yields and purity.

An efficient protocol to synthesize a series of N-aryl pyrazoles via C-N bond Chan-Lam coupling reaction using diverse boronic acid at room temperature using Cu(OAc)2/TEA as a catalytic system without utilization of any ligand or additive and exposed to air to afford moderate to excellent yield. The characterizations of newly synthesized compounds were confirmed by FTIR, MS, 1H NMR, 13C NMR, and elemental analysis. All the synthesized compounds were assayed for their antibacterial activity against Staphylococcus aureus MTCC-96, Escherichia coli MTCC-443, B. subtilis MTCC-441, S. typhi MTCC-98, and antifungal activity against Aspergillus niger MTCC-282 and Aspergillus clavatus MTCC-1323 at different concentration and compared with standards drugs. The minimum inhibition concentration (MIC) of the compounds was studied by micro broth dilution method.