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The Space-Time Variational Multiscale (ST-VMS) method was introduced to function as a moving-mesh method. It is the VMS version of the Deforming-Spatial-Domain/Stabilized ST (DSD/SST) method. It has reasonably good turbulence modeling features and serves as a core computational method. The ST Slip Interface (ST-SI) method was introduced to addresses the challenge involved in high-resolution representation of the boundary layers near spinning solid surfaces. The mesh covering a spinning solid surface spins with it and thus maintains the high-resolution representation near it. The ST-TC method was introduced for moving-mesh computation of flow problems with topology changes, such as contact between solid surfaces. It deals with the TC while maintaining high-resolution boundary layer representation near solid surfaces. The "ST-SI-TC" method we introduce here integrates the ST-SI and ST-TC methods in the ST-VMS framework. It enables accurate flow analysis when we have a spinning solid surface that is in contact with a solid surface. We present two test computations with the ST-SI-TC method, and they are both with models of flow around a rotating tire with road contact and prescribed deformation, one with a 2D model, and one with a 3D model.

Glycogenic hepatopathy (GH) is a rare complication of poorly controlled type 1 diabetes mellitus (T1DM), and is characterized by elevated liver enzymes, hepatomegaly, and glycogen accumulation. We herein present the case of a 23-year-old man with poorly controlled T1DM who had liver dysfunction. Imaging studies showed severe hepatomegaly and fatty liver. The examination of a liver biopsy specimen revealed fatty droplets, ballooning, inflammation, and mild fibrosis. Subsequent periodic acid-Schiff (PAS) staining after diastase digestion confirmed GH. In this case, the improvement of hyperglycemia, not HbA1c, resulted in the improvement of the patient's liver function. This is the first report on the use of continuous glucose monitoring in patients with GH to show that continuous hyperglycemia may worsen GH.

Background/Aim: Sarcopenia increases the mortality in patients with cirrhosis. Approximately 60% of zinc is accumulated in skeletal muscle. We aimed to determine the role of subclinical zinc deficiency on sarcopenia development in patients with cirrhosis. Patients and Methods: We enrolled 151 patients with cirrhosis and divided them into the group with normal serum zinc levels (Group N: 80-130 μg/dl; n=38) and group with subclinical zinc deficiency (Group D: <80 μg/dl; n=113). The risk factors for sarcopenia were then investigated. Results: Group D had more sarcopenia cases than Group N (31.0% vs. 13.2%). In group D, HGS exhibited a weakly positive but significant correlation with serum zinc levels (R=0.287, p=0.00212), serum zinc levels negatively correlated with both ammonia and myostatin levels (R=−0.254, p=0.0078; R=−0.33, p<0.01), and low zinc levels were independently associated with sarcopenia development. Conclusion: Patients with cirrhosis showing subclinical zinc deficiency have a significantly higher risk of developing sarcopenia.