Background: Multiple Sclerosis (MS) disease is a chronic, debilitating, and often progressive inflammatory disease of the central nervous system that is affected by cognitive and emotional dimensions, and also, this disease affects these dimensions. Objectives: This study was carried out to determine the effect of executive functions on the tolerance and quality of life of MS patients. Materials & Methods: In this cross-sectional study, 290 MS patients were selected as the sample size by simple random sampling method from the statistical population consisted of all 687 patients with MS disease in Gorgan’s MS Association, Gorgan City, Iran, in 2020. To collect data, we used Nejati’s executive functions questionnaire, McGuigan and Hutchinson’s quality of life questionnaire, and Simons and Gaher’s tolerance scale. Path analysis by SPSS V.18 and AMOS V.23 software was used for data processing. Results: According to the results of path analysis, executive functions affect -0.371 and tolerance -0.257 on the quality of life (P=0.01), and in total, that can explain 44% of the variance. Also, tolerance mediates the relationship between executive function and quality of life. Conclusion: Executive function is related to the quality of life of MS patients by the mediating role of tolerance, in the sense that a higher ability to tolerate increases the constructive effect of executive function on improving the quality of life.

Background: Multiple Sclerosis (MS) is affected by cognitive and emotional factors. The aim of this study was to investigate the relationship between sensitivity to anxiety and executive functions and the Quality of Life (QoL) of MS patients using path analysis. Methods: This descriptive correlational research was done on all patients with MS in Gorgan MS Association in 2020. The sample size was considered to be 290 people according to the sample selection formula and based on the values obtained from the previous study selected by simple random sampling. To collect data, the Executive Functions Questionnaire of Nejati (2013), QoL questionnaire of McGuigan & Hutchinson (2004), and Sensitivity to Anxiety Questionnaires of Taylor and Cox (1998) were used. Path analysis with SPSS v. 18 and AMOS v. 23 software was used to analyze the data. Results: The results showed that the executive functions had a positive relationship with QoL in MS patients and sensitivity to anxiety had a negative relationship with QoL in MS patients. Also, mediating role of the anxiety sensitivity variable in the relationship between executive functions with QoL in MS patients was confirmed (P≤0.01). Conclusion: The present study indicated the importance of cognitive factors, such as executive functions, and emotional factors, such as sensitivity to anxiety in explaining the QoL in MS patients.