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Background and aimsThe study of the course of the disease in patients previously ill with COVID-19 infection would contribute to adjusting approaches to the treatment of such patients in order to improve the efficiency of the cure. MethodsWe observed 45 patients previously ill with COVID-19 and admitted with a diagnosis of ischemic stroke and apply the Sf-36, MOCA, HADS, Rivermide, Rankin and NIHHS scales, of these, 44.4% (20) were women, and 55.6% (25) were men. The average age of patients was 61.2 (52-74) years. The control group of patients, also with ischemic stroke, but without Covid-19 disease in anamnesis, also consisted of 45 people, 48.9% ( 22) were women and 51.1% (23) were men. The average age of patients was 62.8 (53-78) years. ResultsIn 42 patients previously ill with COVID-19, significant results of the studied indicators indicating a more severe course of the disease were observed compared to those in the control group. At the same time, no significant differences were observed among men and women. In the group of patients who had not previously suffered from COVID-19, only 6patients (13.3%) also suffered from the disease. The majority of these patients were men aged 63 and above. ConclusionsThe results of the studies indicate a strong influence of the fact of the previously suffered infection COVID-19 on the nature and duration of the course of ischemic stroke. A history of COVID-19 should contribute to the revision of treatment tactics and the intensity of interventions and be prepared for a longer process of rehabilitation procedures.