A pyrene-fused subphthalocyanine synthesized from a reaction of 2,7-di-tert-butyl-4,5,9,10-tetracyanopyrene and tetrafluorophthalonitrile exhibits red-shifted Q-band absorption and a unique linear arrangement in the solid state caused by a π-π stacking interaction. The concave conjugation of the SubPc moiety and the planar conjugation of the pyrene moiety enhanced its co-crystallization with C(60) molecules.

The introduction of a seven-membered-ring unit in the place of a five-membered-ring unit in the structure of subphthalocyanine resulted in significant distortion of the bowl-shaped structure of the conjugated molecule as well as the following unprecedented properties: the preferential formation of the axially fluoro substituted species, the fluttering-dynamic-motion-induced rapid exchange of P and M enantiomers, markedly split Q-band absorption, and a clear difference in the ring-current effects arising from the convex and concave surfaces.

DNase 1-like 3 (DNase1L3), which belongs to DNase1 family, was originally identified as one of apoptosis-and necrosis-related endonucleases that fragmentate intranucleosomal DNA. A loss-of-function mutation has been reported in murine models of systemic lupus erythematosus (SLE) and in familial SLE patients. These reports suggest DNase1L3 plays an important role in the prevention of developing SLE; however, expression and function of DNase1L3 in human immune systems have been largely unclarified. As previous reports showed DNase1L3 is expressed in hematopoietic organs, we first analyzed expression levels of DNase1L3 in each subset of human peripheral blood cells by quantitative real-time PCR. Plasmacytoid dendritic cells showed the highest expression levels of DNase1L3 mRNA among peripheral blood cells. IL-4 enhanced DNase1L3 expression in monocytes, monocyte-derived dendritic cells, and monocyte-derived macrophages (MDMs), but not in T cells, B cells, or plasmacytoid dendritic cells. Together with IL-4, all-trans retinoic acid and apoptotic cells efficiently upregulated expression of DNalse1L3 in MDMs. As a result of intracellular signaling analysis, Jak1-IRS2-ERK/PI3K pathway was essential for IL-4-induced DNase1L3 expression. IL-4-treated monocyte-derived dendritic cells and MDMs secreted active DNase1L3 protein that could degrade liposome-DNA complexes, which were resistant to DNase1. Our results indicate DNase1L3 is secreted by innate immune cells and may play a critical role in the tissue homeostasis and on prevention of developing autoimmunity by degrading self-DNA.

Few-layered antimonene (FLSb) nanosheets were noncovalently functionalized with fullerene C 60 clusters by quick addition of ap oor solvent( i.e.,a cetonitrile) into a mixed dispersion of FLSb and C 60 in ag ood solvent( i.e.,t oluene). In aflash-photolysis time-resolved microwaveconductivity (FP-TRMC) measurement, the FLSb-C 60 composite, (FLSb + C 60 ) m ,s howed ar apid rise in transient conductivity, whereas no conductivity signal was observed in the single components,F LSb and C 60 .T his demonstrated the occurrence of photoinduced charges eparation between FLSb and C 60 in (FLSb + C 60 ) m .F urthermore, ap hotoelectrochemical devicew ith an electrophoretically deposited (FLSb + C 60 ) m film exhibited an enhanced efficiencyofphotocurrent generation, compared to those of the single-components, FLSb and C 60 ,d ue to the photoinduced charge separation between FLSb and C 60 .T his work provides ap romising approach for fabrication of antimonene-organic molecule compositesa nd paves the way for their application in optoelectronics.

A combination regimen of biweekly paclitaxel and oral S-1 was well tolerated and showed promising activity against unresectable and recurrent gastric cancer.