The continuous increase in pathogenic viruses and the intensive laboratory research for development of novel antiviral therapies often poses challenge in terms of cost and time efficient drug design. This accelerates research for alternate drug candidates and contributes to recent rise in research of antiviral peptides against many of the viruses. With limited information regarding these peptides and their activity, modifying the existing peptide backbone or developing a novel peptide is very time consuming and a tedious process. Advanced deep learning approaches such as generative adversarial networks (GAN) can be helpful for wet lab scientist to screen potential antiviral candidates of interest and expedite the initial stage of peptide drug development. To our knowledge this is the first ever use of GAN models for antiviral peptides across the viral spectrum. In this study, we develop PandoraGAN that utilizes GAN to design bio active antiviral peptides. Available antiviral peptide data was manually curated for preparing highly active peptides data set to include peptides with lower IC50 values. We further validated the generated sequences comparing the physico-chemical properties of generated antiviral peptides with manually curated highly active training data. Antiviral sequences generated by PandoraGAN are available on PandoraGAN server.

Understanding the star-formation properties of galaxies as a function of cosmic epoch is a critical exercise in studies of galaxy evolution. Traditionally, stellar population synthesis models have been used to obtain best fit parameters that characterise star formation in galaxies. As multiband flux measurements become available for thousands of galaxies, an alternative approach to characterising star formation using machine learning becomes feasible. In this work, we present the use of deep learning techniques to predict three important star formation properties -stellar mass, star formation rate and dust luminosity. We characterise the performance of our deep learning models through comparisons with outputs from a standard stellar population synthesis code.Deep learning is inspired by the synaptic connections of

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Machine Learning algorithms are good tools for both classification and prediction purposes. These algorithms can further be used for scientific discoveries from the enormous data being collected in our era. We present ways of discovering and understanding astronomical phenomena by applying machine learning algorithms to data collected with radio telescopes. We discuss the use of supervised machine learning algorithms to predict the free parameters of star formation histories and also better understand the relations between the different input and output parameters. We made use of Deep Learning to capture the non-linearity in the parameters. Our models are able to predict with low error rates and give the advantage of predicting in real time once the model has been trained. The other class of machine learning algorithms viz. unsupervised learning can prove to be very useful in finding patterns in the data. We explore how we use such unsupervised techniques on solar radio data to identify patterns and variations, and also link such findings to theories, which help to better understand the nature of the system being studied. We highlight the challenges faced in terms of data size, availability, features, processing ability and importantly, the interpretability of results. As our ability to capture and store data increases, increased use of machine learning to understand the underlying physics in the information captured seems inevitable.