The medicinal importance of fungi should not be ignored as it plays an important role in elds like Ayurvedic dravyaguna and pharmacognosy. Ganoderma lucidum was reported with rich medicinal properties due to having good number of medicinal compounds. Ganoderma lucidum, an oriental medicinal fungus showing a variety of biological activities like anticancer activity, anti-diabetic activity, hypoglycemic effect, antimicrobial and antioxidant properties. Candida, Enterococcus, Staphylococcus spp, Streptococcus spp, Escherichia, Pseudomonas are leading pathogens present on ear, nose and throat region. In the present decades, there is a much gaining attention to scientists in green synthesis of silver nanoparticles. The present paper provides information about the Medicinal properties and Economic importance AgNP from Ganoderma lucidum.