Highlight: The present report reveals for the first time natural lentiviral infection of wild Indian NHPs, rhesus monkeys (Macaca mulatta) and langurs (Semnopithecus entellus) by SIVs that are phylogenetically diverse from all known SIVs, including "SIVmac", which infects captive rhesus monkeys. The novel SIVs are intriguingly homologous to HIV-1, based on serology and partial lentiviral genomic sequence analyses. Diverse lentiviruses infect human and nonhuman primates (NHPs). There are more than 45 different "species-specific" simian immunodeficiency viruses (SIVs) that infect their cognate NHP hosts in natural habitats in Africa. Indian NHPs are not known to be infected by SIVs in the wild. Conventionally SIVs are named after their natural hosts, except for SIVmac, which infects captive rather than wild rhesus macaques. SIVmac is therefore a misnomer. It is a genetic variant of the African SIVsmm, which infects wild African sooty mangabey monkeys. SIVsmm is the progenitor of human immunodeficiency virus (HIV-2), while SIVcpz that infects wild chimpanzees is the progenitor of HIV-1. Although natural infections cannot be easily studied in wild NHP populations, we have previously reported co-infection of wild Indian NHPs by other retroviruses: simian retroviruses (SRVs) and Simian Foamy viruses (SFV). Apart from zoonosis, transmission of pathogens from humans to animals: anthroponosis, has also been reported in literature.

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Most viral pathogens causing epidemics and pandemics are zoonotic, emerging from wildlife reservoirs like SARS CoV2 causing the global Covid-19 pandemic, although animal origin of this virus remains a mystery. Cross-species transmission of pathogens from animals to humans is known as zoonosis. However, pathogens are also transmitted from humans to animals in regions where there is a close interaction between animals and humans by ‘reverse transmission’ (anthroponosis). Molecular evidence for the transmission of two zoonotic RNA viruses at the human-monkey interface in Rajasthan forests is presented here: a) the apathogenic Simian Foamy Viruses (SFV), and b): Influenza A viruses (IAV)-like virus, etiologic agent for human flu infecting wild Indian rhesus monkeys inhabiting Rajasthan forests. The data provide critical information on ecology and evolution of viruses of Public Health relevance. During replication, viral genomes mutate along the transmission route to adapt to the new hosts, generating new variants that are likely to have properties different from the founder viruses. Wild Indian monkeys are under-sampled for monitoring infectious diseases mainly because of the difficulties with sample collection. Monkeys are perceived as religious icons by the Hindus in India. It is extremely difficult to obtain permission from the Forest and Wildlife Department government authorities to collect wild simian blood samples for surveillance of infectious diseases caused by viral pathogens. Reducing animal-human contact and affordable vaccination are two relevant anti-viral strategies to counteract the spread of infectious zoonotic pathogens. Genbank Accession numbers : Indian SFVmac: ADN94420, IAV like virus: MZ298601.

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