Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) rose without precedent for Wuhan, China, in December 2019. It is a kind of exceptionally pathogenic human coronavirus (HCoV) which causes zoonotic sicknesses and represents a significant risk to general wellbeing. Recognizing the hidden biology and pathogenesis of this novel coronavirus is extremely critical to comprehend as well as boosting the treatment of this deadly pandemic. The point of this study is to recognize key genes which show significant expression in the SARS-CoV-2 infected lungs as compared to healthy ones. Our analysis uncovered 149 gene-signatures that show substantial up-regulation in COVID-19 lungs. Out of these, top ten dysregulated genes STAP1, CASP5, FDCSP, CARD17, ST20, AKR1B10, CLC, KCNJ2-AS1, RNASE2 and FLG are found to be significant based on various crucial statistical factors and may end up being acceptable helpful drug targets.

Hantaviruses are zoonotic pathogens that have severe harmful effects on humans. They belong to a completely different genus in the Bunyaviridae family as they are rodent-borne viruses. They have a persistent life cycle in their primary hosts without causing any infection, however, they can infect humans in case of any contact with rodents or inhalation of aerosolized contaminated rodent droppings or saliva. Hantavirus has a wide geographic dispersal and is found in all the continents except Antarctica. Since their first encounter in the 1950s during the Korean conflict, it has been a threat to humans. Hantavirus syndrome can result in either Hemorrhagic Fever with Renal Syndrome (HFRS), which is more prevalent in America, and Hantavirus Cardiopulmonary Syndrome (HCPS) prevalent in Eurasia. These viruses have caused approximately 2,00,000 infections worldwide in recent years. In this review, we provide a summary of the progress made in understanding the hantavirus epidemiology, different vaccines, drugs, pathogenesis, clinical features, model systems used for hantavirus studies, treatments, and preventions associated with the virus.