Telehealth refers to the usage of any electronic materials in the form of voice, images, documents, etc. The aim: to examine the effect of asynchronous mobile health nursing intervention on medications adherence and quality of life among patients with psoriasis. Design: A quasiexperimental research design. Subjects: A purposive sample including 60 patients who were admitted to the dermatology outpatient clinics, were divided randomly into the study and control group of 30 patients in each. Setting: This research was conducted at a university hospital dermatology clinic. Instruments of the study: (I): Structured interview questionnaire. (II): Modified 12-Item Medication Adherence Scale. (III): Dermatology Life Quality Index. Results:The mean of knowledge score, adherence level was increased, and improve quality of life index increased significantly throughout the phases of the intervention among study group subjects with statistically significant differences existed between them. Conclusion: Using (mobile health) in education about psoriasis and its management significantly improving total knowledge score, medications adherence improved the quality of life. Recommendations: designing different mobile patient engagement applications to provide a simple way for follow-up, and education. Replication of the study using a large number of subjects, and longer follow-up time to permit a chance for results generalization.