A quasi-experimental; two group concurrent pre-test, post-test design was conducted to evaluate the effectiveness of Constructive Teaching Program (CTP) and Self-Instructional Module (SIM) on knowledge regarding Breast Cancer among 20 B.Ed students of selected B.Ed college who were divided into two groups (10 in Group-I with CTP and 10 in Group-II with SIM) were selected using Probability; Simple random sampling technique. Instruments used to measure the effectiveness are: Demographic variables and Structured Knowledge Questionnaire on various aspects of Breast cancer. Findings revealed that the 'Fcal value (57.2*) is greater than the 'Ftab value (4.41). This indicates that the mean gain in knowledge scores of B.Ed students in Group-I who were exposed to Constructive Teaching Program was higher than those in the Group-II who were exposed to Self-Instructional Module. This signifies CTP is more effective than SIM.