Loss of memory is a major problem in old age population. Curcumin used to treats the various neurological disorders. Curcumin possess the ameliorative potential in toxin induced neurocognitive function.

Loss of memory is a major problem in old age population. Curcumin used to treats the various neurological disorders. Curcumin possess the ameliorative potential in toxin induced neurocognitive function. ABSTRACTCurcumin is a major phyto-constituent of Curcuma longa. It has been reported that it that it showed various pharmacological actions via anti-oxidant, anti-inflammatory, and immunomodulatory actions. The present study undergoes the therapeutic evaluation of curcumin in cigarette smoke extract (CSE) exposure induced cognitive impairment in zebrafish. Methods: The cognitive impairment was induced by exposure to 25 ml of 200 % CSE; 10 minutes/day, for 7 consecutive days. The pre-treatment of curcumin (10 and 20 mg/kg) and montelukast(20 mg/kg) were exposed in 25 ml drug solution (10 minutes/day for 10 consecutive days). The changes of CSE induced cognitive dysfunction were evaluated by using different test methods such as colour recognition test; partition preference test;horizontal compartment test; and T-Maze tests. Further, the CSE exposure induced changes of biochemical parameters i.e., acetylcholinesterase activity; lipid peroxidation; reduced glutathione; and total protein levels were estimated in the brain of zebrafish. The preexposure of curcumin shown to produce the ameliorative effect against CSE induced neurocognitive impairments along with alteration of biochemical changes. Theseresults were comparable to reference control i.e., montelukast pre-treated group. Therefore, the curcumin can be served as newer medicines for immunological reaction associated neurocognitive disorders like Alzheimer and multiple sclerosis due to its potential anti-oxidative; antiinflammatory; immunomodulatory; and acetylcholinesterase inhibitory actions.as an adjunctive treatment for co-morbid cannabis use disorder and cigarette smoking. Addict Behav 79, 86-92.