Objective: The aim was to study of multiorgan dysfunction in patients with dengue and to correlate the severity and clinical outcome with different hematological parameters.Methods: All suspected cases of dengue admitted to medicine department within 1 year were evaluated and classified as dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS). Results:Out of 150 cases, 108 cases were classified as DF, 31 cases as DHF and 11 cases as DSS. Liver involvement was seen in 97.33% of cases. Jaundice was observed in 10 cases (6.6%), abnormal aspartate transaminase in 146 (97.33%) cases, and abnormal alanine transaminase in 126 (84%) cases. Bleeding manifestations was reported in 61 patients (40.6%). The presence of gastrointestinal bleeding in 17 patients (11.3%) was related to severe disease. Thrombocytopenia was present in 25% of DF cases, and in all cases of DHF and DS. Among these, prothrombin time (PT) was prolonged in 10 cases and activated partial thromboplastin time (aPTT) in 47 patients. Serum fibrinogen was low in 28.57% of patients. Multiorgan dysfunction was observed in the form of simultaneous hepatic and renal dysfunction in 3.33% of cases, hepatic and central nervous system dysfunction in 2.66% of cases, hepatic and cardiac dysfunction in 2% of cases, and all the organ system dysfunction in 0.67% of cases. Conclusion:The extent of increase of liver enzymes, PT, aPTT and fall of serum fibrinogen, and degree of thrombocytopenia correlated with disease severity. Acute renal failure, encephalitis, and myocarditis are manifestations of severe form of dengue. Major organ involvement may occur in simple DF also.