a b s t r a c tObjective: The aim of this study to assess the utility of 128-MDCT VHSG in evaluation of different female infertility causes. Patients and methods: Forty eight infertile female patients were included in the study, which was conducted in Radiodiagnosis Department, Zagazig University Hospitals from November 2014 to May 2015. MDCT Hysterosalpingography was performed between days 6 and 12 of the menstrual cycle at least 48 hours after menses. Results: we compared findings of MDCT-VHSG with hysteroscopy or/ and laparoscopy results. We found that MSCT-VHSG more accurate in diagnosis of uterine and ovarian infertility causes, while less accurate in the diagnosis of tubal causes. The sensitivity for detecting uterine and fallopian tubes pathology by MDCT-VHSG was 100% and 100% respectively, while the specificity was 100%, 85.71% respectively. MDCT-VHSG had reported 100% and 92.85% PPV in detecting uterine and fallopian tubes pathology respectively, while the NPV was 100% and 100% respectively. Conclusion: The MDCT-VHSG is a diagnostic modality which permits the evaluation of the different causes of the female infertility, but still limited value in assessment of peritubal adhesions.