Quasi-static compression experiments are performed on two kinds of the PTFE/Al/W reactive material specimens, fabricated by means of the cold isostatic pressing but not sintering or the pressing followed by sintering, respectively. The results show that, compared with the pressed specimens, the sintered specimens show higher failure stress and greater fracture toughness. Moreover, the mesoscale failure behaviors are significantly influenced by the sintering technique and the component ratios. There are significantly different bonding and dispersion type of the PTFE matrix between the pressed specimen and the sintered specimen, resulting in the differences of mechanical properties and failure behavior between the two kinds of specimens.