As articular cartilage has very limited self-repair capability, the repair and regeneration of damaged cartilage is a major challenge. This review aims to outline the past, present, and future of cell therapies for articular cartilage defect repair. Autologous chondrocyte implantation (ACI) has been used clinically for more than 20 years, and the short, medium, and long-term clinical outcomes of three generation of ACI are extensively overviewed. Also, strategies of clinical outcome evaluation, ACI limitations, and the comparison of ACI clinical outcomes with those of other surgical techniques are discussed. Moreover, mesenchymal stem cells and pluripotent stem cells for cartilage regeneration in vitro, in vivo, and in a few clinical studies are reviewed. This review not only comprehensively analyzes the ACI clinical data but also considers the findings from state-of-the-art stem cell research on cartilage repair from bench and bedside. The conclusion provides clues for the future development of strategies for cartilage regeneration.
The CEDE is a useful instrument for the study of the growing clinical problem of the eating disorders in Mainland China. The finding that the characteristic fat phobia is prominent in this population of eating disordered patients and its implication on the identity and classification of the eating disorders are discussed.
Two new microporous polyoxomolybdates of (NH4)2[γ-Mo8O26] (Compound I) and (NH4)2[Mo4O13] (Compound II) were synthesized hydrothermally and characterized by elemental analysis, infra-red, TG analysis and single-crystal X-ray diffraction. In the synthesis process, we found that both organic template and transition metal salt play crucial roles in the formation of crystals. Cyclic voltammetry was used to study their electrochemical properties. The results reveal that the two compounds possess electrochemical activity in 0.2M H2SO4+Na2SO4 ( pH=1 ) solution and three multi-electron transferred redox reaction (I-I´, II-II´ and III-III´) processes were obtained. The first two redox reactions (I-I´, II-II´) are reversible reaction processes but another one (III-III´) is not. The electrochemical properties of the two compounds indicate their great potential applications in electroanalysis and electrocatalysis.
Our project team designed and realized an Automatic Identification System (AIS) terminal equipment specifically which is based on an ARM7 chip and compatible with a self-developed FPGA chip. The main research topic is about the timeslot management and implementation in this equipment. I designed a timeslot list in the form of an array, to storage every timeslot state in each channel and current frame real-time, intuitively, and conveniently. When there is a timeslot-occupied or a timeslot-reserved in the equipment, the timeslot list can storage the timeslot state real-time. This timeslot state is defined as whether each timeslot is currently occupied, what action occupied it, how long the timeout is. And manage the timeslot every timeslot by timeout, to realize each timeslot management in A/B channels. When the equipment will select candidate timeslots to send message, it could read the timeslot state by the timeslot number directly to know whether it can send message in this timeslot. Make sure its timeslot reuse, prevent its timeslot collision, and realize the communication real-time and effective.
A differential phase error detector is inserted in the carrier loop structure for improving the dynamic performance of the loop in GNSS receiver in this paper. It is used to detect the abnormal phase jitter and amplify the adjusting increment for fast tracking. In order to avoid the differential detector amplifying noise interference in locking, fuzzy logical theory is introduced into the loop to control the amplification caused by the differential detector. Finally simulations show that the proposed design achieves high dynamic performance with effectively speeding up the tracking and widening the dynamic stress range.
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