Background Radioresistance is one of the main obstacle limiting the therapeutic efficacy and prognosis of patients, the molecular mechanisms of radioresistance is still unclear. The purpose of this study was to identify the key genes and miRNAs and to explore their potential molecular mechanisms in radioresistant nasopharyngeal carcinoma. Methods In this study, we analysis the differentially expressed genes and microRNA based on the database of GSE48501 and GSE48502, and then employed bioinformatics to analyze the pathways and GO terms in which DEGs and DEMS target genes are involved. Moreover, Construction of protein-protein interaction network and identification of hub genes. Finally, analyzed the biological networks for validated target gene of hub miRNAs. Results A total of 373 differentially expressed genes (DEGs) and 14 differentially expressed microRNAs (DEMs) were screened out. The up-regulated gene JUN was overlap both in DEGs and publicly available studies, which was potentially targeted by three miRNAs, including hsa-miR-203, hsa-miR-24 and hsa-miR-31. Moreover, Pathway analysis showed that both up-regulated gene and DEMs target genes were enriched in TGF-beta signaling pathway, Hepatitis B, Pathways in cancer and p53 signaling pathway. Finally, we further constructed protein-protein interaction network (PPI) of DEGs and analyzed the biological networks for above mentioned common miRNAs, the result indicated that JUN was a core hub gene in PPI network, hsa-miR-24 and its target gene were significantly enriched in P53 signaling pathway. Conclusions These results might provide new clues to improve the radiosensitivity of Nasopharyngeal Carcinoma. Electronic supplementary material The online version of this article (10.1186/s12920-019-0507-6) contains supplementary material, which is available to authorized users.

Soil respiration can be altered by changing substance supply, respiratory capacity and the demand for the products. We carried out a field experiment in the northeast of China to understand how inoculation with arbuscular mycorrhizal fungi (AMF) alters soil respiration in paddy fields. Soil respiration and factors contributing to it were measured for paddy fields either inoculated or non-inoculated with AMF, with or without fertilization. We found that inoculation increased soil respiration, net photosynthesis of rice leaves, N and P content of rice shoots and the abundance of actinomyces and fungi in rhizosphere; while the negative effect was only observed on root biomass. We also found that fertilization decreased the responses of soil respiration, root biomass and the abundance of bacteria and fungi in rhizosphere to inoculation. However, it decreased the responses of net photosynthesis, shoot biomass and shoot N and P content to inoculation. Conclusively, AMF inoculation promoted soil respiration by enhancing substrate supply, respiratory capacity and the demand for products; while the impacts of inoculation were weakened by fertilization via respiration capacity and the demand for the products.