In the present study, a new coamorphous phase (CAP) of bioactive herbal ingredient curcumin (CUR) with high solubilitythe was screened with pharmaceutically acceptable coformers. Besides, to provide basic information for the best practice of physiological and pharmaceutical preparations of CUR-based CAP, the interaction between CUR-based CAP and bovine serum albumin (BSA) was studied at the molecular level in this paper. CAP of CUR and piperazine with molar ratio of 1:2 was prepared by EtOH-assisted grinding. The as-prepared CAP was characterized by powder X-ray diffraction, modulated temperature differential scanning calorimetry, thermogravimetric analysis, Fourier-transform infrared, and solid-state C nuclear magnetic resonance. The 1:2 CAP stoichioimetry was sustained by C═O···H hydrogen bonds between the N-H group of the piperazine and the C═O group of CUR; piperazine stabilized the diketo structure of CUR in CAP. The dissolution rate of CUR-piperazine CAP in 30% ethanol-water was faster than that of CUR; the t values were 243.1 min for CUR and 4.378 min for CAP. Furthermore, interactions of CUR and CUR-piperazine CAP with BSA were investigated by fluorescence spectroscopy and density functional theory (DFT) calculation. The binding constants (K) of CUR and CUR-piperazine CAP with BSA were 10.0 and 9.1 × 10 L mol at 298 K, respectively. Moreover, DFT simulation indicated that the interaction energy values of hydrogen-bonded interaction in the tryptophan-CUR and tryptophan-CUR-piperazine complex were -26.1 and -17.9 kJ mol, respectively. In a conclusion, after formation of CUR-piperazine CAP, the interaction forces between CUR and BSA became weaker.

The origin of the gamma-ray burst (GRB) X-ray plateau, especially the internal plateau, is still unclear, but it could be related to a GRB’s magnetar central engine. It is generally believed that the spin-down power of the magnetar is injected into forward external shock; however, we propose here that most of the power will be dissipated behind the GRB jet through a larger amplitude electromagnetic wave. Based on this proposal, the relevant physical conditions and observational implications are analyzed and discussed, and various kinds of X-ray light curves could be reproduced. Although the chromatic multiband afterglow in the standard external afterglow fireball model is still a matter of debate, we can naturally explain this feature through this proposal, i.e., the electrons generating the X-ray plateau and emitting the optical afterglow are accelerated by different mechanisms. It is emphasized that both the GRB jet and the spin-down wind should have significant observational consequences in the magnetar scenario, and should be focused equally in GRB physics.

A rapidly spinning, strongly magnetized neutron star is invoked as the central engine for some Gamma-ray bursts (GRBs), especially, the "internal plateau" feature of X-ray afterglow. However, for these "internal plateau" GRBs, how to produce their prompt emission remains an open question. Two different physical process have been proposed in the literature, (1) a new-born neutron star is surrounded by a hyper-accreting and neutrino cooling disk, the GRB jet can be powered by neutrino annihilation aligning the spin axis; (2) a differentially rotating millisecond pulsar was formed due to different angular velocity between the interior core and outer shell parts of the neutron star, which can power an episodic GRB jet. In this paper, by analyzing the data of one peculiar GRB 070110 (with internal plateau), we try to test which model being favored. By deriving the physical parameters of magnetar with observational data, the parameter regime for initial period (P 0 ) and surface polar cap magnetic field (B p ) of the central NS are (0.96 ∼ 1.2) ms and (2.4 ∼ 3.7) × 10 14 G, respectively. The radiative efficiency of prompt emission is about η γ ∼ 6%. However, the radiative efficiency of internal plateau (η X ) is larger than 31% assuming the M NS ∼ 1.4M ⊙ and P 0 ∼ 1.2 ms. The clear difference between the radiation efficiencies of prompt emission and internal plateau implies that they maybe originated from different components (e.g. prompt emission from the relativistic jet powered by neutrino annihilation, while the internal plateau from the magnetic outflow wind).

The solubilization of two salts and one salt-cocrystal of dipfluzine was revealed by supramolecular structures combined with lattice energies.