ObjectiveTo investigate the effects of Chinese herb Danzhi Xiaoyao pills on the pharmacokinetics of venlafaxine and its metabolites O-desmethylvenlafaxine (ODV) and N-desmethylvenlafaxine (NDV) in beagles by using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS).MethodsSix beagles (half male, half female) were chosen to test, being fasted before the experiment but having free access to drinking water 1 day before being fed drugs. After oral administration of venlafaxine hydrochloride tablets (10.28 mg/kg), the blood samples were collected in succession at different points in time. After 1-week washout period, Danzhi Xiaoyao pills (0.6g/kg) were given through oral administration to the six beagles every morning until the 7th day, venlafaxine hydrochloride tablets (10.28 mg/kg) were given after feeding Danzhi Xiaoyao pills (0.6g/kg) half an hour and blood samples were collected continuously at different points. All samples were analyzed by UPLC-MS/MS, and the main pharmacokinetic parameters of venlafaxine, ODV and NDV were computed by DAS 2.0.ResultsThe Cmax of the venlafaxine group (control group) and the combination group (experimental group) were (2267.26±252.89) ng/mL and (1542.64±190.73) ng/mL, respectively. The AUC(0-∞) of the two groups were (13,934.79±3609.23) ng·h/mL and (8001.91±2167.58) ng·h/mL, respectively. The ODV Cmax of the two groups were (2253.80±215.81) ng/mL and (2721.37±118.20) ng/mL, and AUC(0-∞) were (13,974.99±2784.04) ng·h/mL and (17,539.44±1894.29) ng·h/mL, respectively. The NDV Cmax of the two groups were (50.98±5.76) ng/mL and (58.74±12.33) ng/mL, and AUC(0-∞) were (179.26±34.94) ng·h/mL and (220.68±51.41) ng·h/mL, respectively. After administration of Danzhi Xiaoyao pills, the Cmax and AUC(0-∞) of venlafaxine decreased significantly, indicating that the plasma exposure of venlafaxine decreased. The increase of Cmax and AUC(0-∞) of ODV and NDV indicated a rise in plasma exposure.ConclusionDanzhi Xiaoyao pills can accelerate the metabolism of venlafaxine in beagles. In clinical, when venlafaxine was co-administrated with Danzhi Xiaoyao pills, dose adjustment of venlafaxine should be taken into account.

In order to make up for the deficiencies due to the molding process,and improve the mechanical properties and sintering performance of self-flow castable,in this paper, we used nano SiO2 which had high surface activity as admixture. We added 0wt%, 0.1wt%, 0.2wt%, 0.3wt% of nano SiO2, and then test the linear change, Flexural strength, compressive strength,and refractoriness under load after dried at 110°Cfor 24h and heat treatment at 1400°C for 8h.The results showed that: with the increase of nano SiO2, self-flow value of self-flow castablel decreased, the flexural strength and compressive strength of the sample increased after dried at 110°C for 24 h, the strength of the self-flow castable was improved after formed.After heat treatment at 1400°C for 8h, linear change of the sample remained the same, Tridymite content, flexural strength and compressive strength increased, apparent porosity decreased, refractoriness under load lowered.

Probing in the energy-efficient coverage problem in Wireless Sensor Networks (WSN), a Discrete Multi-Objective Particle Swarm Optimization (DMOPSO) is proposed based on the characteristics of WSN. A multi-objective energy-efficient coverage strategy is established which focus on reduce the node utilization rate and ensure adequate coverage rate of the sensor networks at the same time based on the improved binary coding schemes. The proposed algorithm is used to solve the established multi-objective coverage problem. The effect of parameters on the optimization effect is analyzed and verified by algorithm analyses and simulations. Simulation result shows that the proposed method effectively reduced the node utilization while keep enough network coverage rate, which reduces network energy consumption and extends network life.

This article focused on the energy limit property of Wireless Sensor Network, and proposed a residual energy based algorithm WN-LEACH, with the classic network mode of LEACH routing algorithm. The algorithm combines the proportion of residual energy in the total energy with the cumulative number of the normal nodes supported by the cluster heads as a cluster selection reference. In order to balance the energy consumption of each cluster-head, the algorithm took both the different positions of the base station and the initial energy of the network into consideration, and weighted the two factors to balance the energy consumption between transmitting the signals and data fusion. Simulation results show that the algorithm can promote the lifetime of the uneven energy network and does not impair the effects of the LEACH algorithm.

Calculate the minimum turning radius of articulated material-carrier in theory, and establish a full-vehicle model for motion simulation to obtain the minimum turning radius with the application of virtual prototype software ADAMS, then compare the theoretical value with simulation value. Analyze the relationship between the position of articulated point in the material-carrier and the minimum turning radius.