Polydopamine (PDA) is the end product of the dopamine monomer's self‐oxidation polymerization process. PDA is gaining popularity in diagnostic and therapeutic purposes because of its unique properties like excellent biocompatibility, biodegradability, surface functionalization, adhesion, and photothermal, which can help in various biomedical applications. Many researchers have been working on polydopamine nanocomposites in recent years. PDA has been used to modify various structures, such as metal nanoparticles, in order to improve the nanosystem's stability and applicability. This review attempts to cover extremely recent works from 2018 to the present in light of recent developments in PDA nanocomposites. The development of novel PDA nanocomposites for therapeutic applications, such as PDA‐metal, PDA‐drug, PDA‐photosensitizers, and PDA‐biomolecules, has been covered in this review. The multiple biomedical applications highlighted in this review include the treatment of cancer, antimicrobial infections, and neurological disorders, as well as wound healing and biosensing. This review will not only help the new researcher to build their base but also for experts to extend their views in this field.

This study reports the synthesis and application of a hybrid lipo-polymeric nanosystem (PDPC NPs) for plasmon enhanced flourescence based NIR imaging and photothermal therapy.

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This paper reports the colorimetric analysis of cervical-cancer-affected clinical samples by the in situ formation of gold nanoparticles (AuNPs) formed with cervico-vaginal fluids collected from healthy and cancer-affected patients in a clinical setup, termed “C-ColAur”. We evaluated the efficacy of the colorimetric technique against the clinical analysis (biopsy/Pap smear) and reported the sensitivity and specificity. We investigated if the aggregation coefficient and size of the nanoparticles responsible for the change in color of the AuNPs (formed with clinical samples) could also be used as a measure of detecting malignancy. We estimated the protein and lipid concentrations in the clinical samples and attempted to investigate if either of these components was solely responsible for the color change, enabling their colorimetric detection. We also propose a self-sampling device, CerviSelf, that could enable the rapid frequency of screening. We discuss two of the designs in detail and demonstrate the 3D-printed prototypes. These devices, in conjugation with the colorimetric technique C-ColAur, have the potential to be self-screening techniques, enabling women to undergo rapid and frequent screening in the comfort and privacy of their homes, allowing a chance at an early diagnosis and improved survival rates.