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Brushite cements have been clinically used for irregular bone defect filling applications, and various strategies have been previously reported to modify and improve their physicochemical properties such as strength and injectability. However, strategies to address other limitations of brushite cements such as low radiopacity or acidity without negatively impacting mechanical strength have not yet been reported. In this study, we report the effect of substituting the beta-tricalcium phosphate reactant in brushite cement with baghdadite (Ca3ZrSi2O9), a bioactive zirconium-doped calcium silicate ceramic, at various concentrations (0, 5, 10, 20, 30, 50, and 100 wt%) on the properties of the final brushite cement product. X-ray diffraction profiles indicate the dissolution of baghdadite during the cement reaction, without affecting the crystal structure of the precipitated brushite. EDX analysis shows that calcium is homogeneously distributed within the cement matrix, while zirconium and silicon form cluster-like aggregates with sizes ranging from few microns to more than 50 µm. X-ray images and µ-CT analysis indicate enhanced radiopacity with increased incorporation of baghdadite into brushite cement, with nearly a doubling of the aluminium equivalent thickness at 50 wt% baghdadite substitution. At the same time, compressive strength of brushite cement increased from 12.9 ± 3.1 MPa to 21.1 ± 4.1 MPa with 10 wt% baghdadite substitution. Culture medium conditioned with powdered brushite cement approached closer to physiological pH values when the cement is incorporated with increasing amounts of baghdadite (pH = 6.47 for pure brushite, pH = 7.02 for brushite with 20 wt% baghdadite substitution). Baghdadite substitution also influenced the ionic content in the culture medium, and subsequently affected the proliferative activity of primary human osteoblasts in vitro. This study indicates that baghdadite is a beneficial additive to enhance the radiopacity, mechanical performance and cytocompatibility of brushite cements.

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Over the years we see that our dependence on the internet has played a major role in all areas of development. We can say that the internet is a common thing among us. This project is a web-app to use for the project appointment scheduling. Along with the patient,there is also a doctor and a super user known as admin. The only administrators have to control all the activities of the project functions. The main motivation of this project is nowadays we are seeing people are facing variousproblems in booking slots of doctor’s available in hospitals for the purpose of medical checkups and surgery etc. For booking the slots of the available doctors. People need to visithospitals by taking various means of transportation and wasting their time traveling. So, we try to avoid transportation and reduce the time in taking an appointment. By using our platform people will easily be able to book their appointment as available to the doctor slots. In this project Online Patient’s Appointment Platform in hospital is necessary for a competent administration when handling patients, the flow of business is determined by the information of the patient, unfortunately the current record management system leads to the misplacement of patient details, the doctor's record of reports, and a lack of security for the records. This research project seeks to automate the whole process of keeping records about Patients, Hospitals, and Doctors. To accomplish this, a comprehensive SystemAnalysis and Investigation was conducted using data collected from existing documents and data flow charts. The concept of report production has been automated, therefore, there is no more delay in receiving reports from the Hospital, Patient, or Doctor. Errors on handheldcalculators have been completely eliminated. The method used to develop the system includes an iterative waterfall model. approach, dataflow, logical and entities relationship diagram were used to design the system and use CSS, SQL server, html and PHP languages.

Gliclazide (GCZ), an antidiabetic medication, has poor solubility and limited oral bioavailability due to substantial first-pass metabolism. Thus, the purpose of the current study was to optimize and formulate a GCZ nanosuspension (NS) employing the antisolvent precipitation technique. A three-factor, three-level Box–Behnken design (BBD) was used to examine the impact of the primary formulation factors (drug concentration, stabilizer, and surfactant %) on particle size. The optimized NS contains 29.6 mg/mL drug, 0.739% lecithin, and 0.216% sodium dodecyl sulfate (SDS). Under scanning microscopy, the topography of NS revealed spherical particles. Furthermore, NS had a much better saturation solubility than the pure material, which resulted in a rapid dissolving rate, which was attributed to the amorphous structure and smaller particle size of the NS particles. Studies on intestinal permeability using the in vitro noneverted intestinal sac gut method (duodenum, jejunum, and ileum) and single-pass intestinal permeability (SPIP) techniques showed that the effective permeability was also increased by more than 3 fold. In the pharmacokinetic study, the Cmax and AUC0–t values of NS were approximately 3.35- and 1.9-fold higher than those of the raw medication and marketed formulation (MF). When compared to plain drug and commercial formulations, the antidiabetic efficacy of NS demonstrated that it had a significant impact on lowering glucose levels.