Paclitaxel, an anticancer drug induced neuropathy is widely used animal model to evaluate new drugs in neuropathy. As oxidative stress is key contributor in pathogenesis of neuropathy, many phenolic acids with antioxidant potential are proven as neuroprotective. So,present work undertaken to evaluate effect of syringic acid and sinapic acid in paclitaxel induced neuropathy. We evaluated effect on mechanical and thermal hyperalgesia and allodynia which are vital signs of neuropathy. 4 weeks treatment by different doses of syringic acid and sinapic acid shown significant protective effect on hyperalgesia and allodynia in dose dependant manner assessed by Randello Selitto, hot plate, cold plate and Von Frey filament test. As these phenolic acids attenuates hyperalgesia and allodynia in neuropathy, can be therapeutically used in combination with current treatment of neuropathy.Summary statementHyperlagesia and allodynia are major signs of neuropathy and this article focus on reduction of hyperalgesia and allodynia by syringic and sinapic acid in neuropathy induced by paclitaxel.

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Oxidative stress is strongly linked to neurodegeneration and oxidative species can modify many amino acids and proteins in the brain. Cysteine amino acid is most susceptible to oxidative post-translational modifications (PTMs). Reversible or irreversible cysteine PTMs can cause dyshomeostasis, which further continued to cellular damage. Many cysteine dependent proteins and many non-proteins using cysteine as their structural components are affected by oxidative stress. Several cysteine dependent enzymes are acting as antioxidants. Cysteine is a major contributor to glutathione (GSH) and superoxide dismutase (SOD) synthesis. Cysteine precursor N-acetylcysteine (NAC) supplementation is proven as a potent free radical scavenger and increase brain antioxidants and subsequently potentiates the natural antioxidant cellular defense mechanism. Thus, in this chapter, the authors explore the linkage of cellular cysteine networks and neurodegenerative disorders.