Background: Amavata (Rheumatoid Arthritis) is a chronic progressive disease, resulted from the conglomeration of Ama and aggrevated Vata dosha which gets lodged in the small joints followed by large joints. If it is left untreated, may cause various complications in the form of Vataja diseases in which Raktadhatu kshaya (Anaemia) and Mutrakricchra (Urinary Tract Infection) are predominant. But it needs robust evidence to revalidate the same. Aim & Objective: To evaluate the association of Raktadhatu kshaya (Anaemia) and Mutrakricchra (Urinary Tract Infection) with Amavata (~Rheumatoid Arthritis). Materials & Methods: A case-control study was conducted from 18.04.2018 to 09.01.2020, containing 155 cases (patients of Amavata), and 163 controls (healthy volunteers), matching in age (between 18 to 50 years), and sex, selected from Jamnagar district.  Health Assessment proforma of TRISUTRA project CSIR-AYURGENOMICS for health assessment,  ACR, 1987 Criteria for RA diagnosis were used. Chi-square test was applied to find the association of Raktadhatu kshaya (Anaemia) and Mutrakricchra (Urinary Tract Infection) with Amavata whereas Unpaired or Mann-whitney U test was applied to compare the hematological parameters between case and control group. Results: Statistically significant differences were found in the mean values of haemoglobin, total leukocyte count, neutrophils, lymphocytes, eosinophils, monocytes, MCV, MCH, MCHC, PCV, total RBC count, and platelet count among both the groups. Microcytic and Dimorphic Anaemia were substantially higher (P<0.0001) in the Amavata patients than in the controls (χ2 value=24.814). The prevalence of UTI (presence of pus cells in the urine) was  found significantly more (P<0.0001) in Amavata patients than healthy individuals (χ2 value=45.347). Conclusion: Anaemia and Urinary tract infections are strongly associated with Amavata (~Rheumatoid Arthritis).

Background: The modern medical community now recognises Amavata as a condition that can lead to Rheumatoid Arthritis (RA) due to a combination of genetic predisposition, poor dietary habits, altered lifestyle, disturbed sleep, disturbed psychological condition, etc. Amavata’s origins are said to be two thousand years old, but there is no rigid evidence to support this. Aim: To evaluate the association of family history, different dietary patterns and lifestyle related risk factors such as Vyayama, improper bowel movements, disturbed/irregular sleep patterns, psychological stress, etc., in the pathology of Amavata (~RA). Materials and Methods: A matched case-control study was conducted from 18 April 2018 to 09 January 2020, containing 150 cases (patients of Amavata), and 150 controls (healthy volunteers), matching in age (between 18-50 years), and both the sexes (1:1 ratio) selected from Jamnagar district. After receiving written informed permission, data were obtained using CRF (Case Record Form). An open-ended questionnaire through the one-to-one interview was used to obtain data on eating habits, psychological and emotional circumstances previous to sickness, lifestyle features such as sleep, Vyayama (physical activity), and bowel patterns. Chi-square tests and Odds Ratios (OR) were computed. Results: The statistical analysis revealed that positive family history (χ2 = 63.021, p<0.001), Avyayama (lack of physical activity) (OR = 7.43, χ2 = 79.95, p<0.001), Diwaswapna (day time sleep) (OR = 12.86, χ2 = 93.048, p<0.001), disturbed night sleep (OR = 44.25, χ2 = 159.61, p<0.001), constipation (OR = 85.17, χ2 = 144.10, p<0.001), Atishrama (occupational stress)(OR = 22.86, χ2 = 96.989, p<0.001), disturbed psychological status (p<0.001) and faulty dietary patterns (p<0.001) were found to have statistically significant association with Amavata (~RA). Conclusion: Strong positive associations were found between positive family history, Avyayama (lack of physical activity), Diwaswapna (daytime sleep), disturbed night sleep, constipation, disturbed psychological status, Atishrama (occupational stress), and faulty dietary patterns (Adhyashana, Vishamashana, Viruddhashana) with Amavata which are statistically significant and they can be considered as the potential risk factors for the incidence of Amavata (~RA).