Hepatocyte nuclear factors (HNFs) exist as an assembly of transcription factors that have a vital role in the expression regulation of genes pertaining to the liver. 1 Conversely, these transcription factors are not restricted to hepatocytes, their expression has been observed in other tissues. 2 There are four major families of HNFs namely HNF1, HNF3, HNF4 and HNF6. The HNF1 family members; HNF1-α/A and HNF-1β/B comprise a POU-homeodomain and bind to DNA as homodimers or heterodimers. 3 Hepatocyte nuclear factor 1B (HNF1B, TCF2) located on chromosome 17q12, 4 belongs to the family of Pit-1, Oct-1/2, UNC-86 (POU) homeodomain-comprising transcription factors (Figure 1). The POU domain is bipartite (POU H and POU S) and is comprised of two subunits separated by a short 15-55 amino acid (aa) non-conserved region. The protein contains three predominant functional

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