Proteins play an important role in organisms. The fast and high-accuracy detection of proteins is demanded in various fields, such as healthcare, food safty, and biosecurity, especially in the background of the globally raging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Optical fiber sensors have great potential for protein detection due to the excellent characteristics of high sensitivity, miniaturization, and capability for remote monitoring. Over the past decades, a large number of structures have been investigated and proposed. This paper begins with an overview of different fiber sensing structures for protein detection according to the fundamental sensing mechanisms. The overview is classified into four sections, including intensity-modulation, phase-modulation, scattering, and fluorescence. In each section, we reviewed the recent advances of fiber protein sensors and compared their performance, such as sensitivity and limit of detection. And then we analyzed the advantages and disadvantages of the four kinds of biosensors. Finally, the paper concludes with the challenges faced and possible future development of optical fiber protein biosensors for further study.

Micromanipulation and biological, materials science, and medical applications often require controlling or measuring the forces exerted on small objects. Based on the high linearity and sensitivity of OAM beams in the sensing field, this article proposes for the first time to apply OAM beams to force sensing. In this paper, a fiber optic force sensing technology based on the intensity distribution change of orbital angular momentum (OAM) mode is proposed and realized. This technique detects the magnitude of the external force applied to the fiber by exciting the OAM mode with a topological charge 3, thereby tracking changes in light intensity caused by mode coupling. Applying this technique to force measurement, we have experimentally verified that when the sensor is subjected to a force in the range of 0mN to 10mN, the change in speckle light intensity at the sensor output has a good linear relationship with the force. Meanwhile, theoretical analysis and experimental results indicate that compared with previous force sensing methods, this sensing technology has a simple structure, is easy to implement, has good stability, and has practical application potential.

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