Silver nanoparticles (AgNPs) was loaded on spherical celluloseimmobilized tannin resin (CC-TA) with AgNO 3 solution as the silver source, where CC-TA was prepared by the cross-linking polymerization of tannin-based pre-polymer and cellulose. The tannin introduced onto the cellulose backbone was used as a reduction reagent for silver ions and a stabilizing agent for AgNPs. The AgNPs are uniform, and the average size is about 6.44 � 3.19 nm. The catalytic activity of AgNPs supported on cellulose-immobilized tannin resin(CC-TA@AgNPs)was detected by the reaction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP). This reaction could be accomplished within 1.5 min with an apparent rate constant of 2.32 min À 1 . The CC-TA@AgNPs has good cycle catalytic performance, and the conversion rate of 4-NP to 4-AP in the presence of CC-TA@AgNPs is about 100 % after five consecutive cycles. Therefore, the CC-TA@AgNPs is expected to be a promising catalytic material.